Serine racemase deletion abolishes light-evoked NMDA receptor currents in retinal ganglion cells
about
Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion.The postnatal development of D-serine in the retinas of two mouse strains, including a mutant mouse with a deficiency in D-amino acid oxidase and a serine racemase knockout mouseAMPA receptor-dependent, light-evoked D-serine release acts on retinal ganglion cell NMDA receptors.Astrocyte-derived thrombospondins mediate the development of hippocampal presynaptic plasticity in vitroGlycine transporter 1 modulates GABA release from amacrine cells by controlling occupancy of coagonist binding site of NMDA receptors.Retinal NMDA receptor function and expression are altered in a mouse lacking D-amino acid oxidaseSerine racemase: an unconventional enzyme for an unconventional transmitter.Serine racemase is expressed in islets and contributes to the regulation of glucose homeostasis.Loss-of-function mutation of serine racemase attenuates excitotoxicity by intravitreal injection of N-methyl-D-aspartate.Serine racemase deficiency attenuates choroidal neovascularization and reduces nitric oxide and VEGF levels by retinal pigment epithelial cells.
P2860
Q30447828-822BAF8A-F416-4D23-9923-93C30DB9E360Q34249737-72A8EC77-AAD1-49C7-8461-CCC673E06371Q36178806-E157849B-8B21-41D0-979E-19CF814C1598Q36331898-8901E776-BA4E-48DC-8694-DD78ACA1326AQ37147481-231BB24B-657B-45B1-AA75-D0522EB40C55Q37441423-D84407A1-8EA0-44BE-81BC-B9C3788CF36CQ38030879-60BB472F-C04E-4755-BC5F-52FC80C081E7Q39158726-B41DC732-A2CA-4A1D-9DAC-EB9FE4A6A547Q40410315-A8F0369D-99EA-49B2-99AD-6819A2B8D757Q47689628-6E6D2070-F71D-42DC-B71E-A1CB0E2DC252
P2860
Serine racemase deletion abolishes light-evoked NMDA receptor currents in retinal ganglion cells
description
article
@en
im Dezember 2011 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в грудні 2011
@uk
name
Serine racemase deletion aboli ...... ents in retinal ganglion cells
@en
Serine racemase deletion aboli ...... ents in retinal ganglion cells
@nl
type
label
Serine racemase deletion aboli ...... ents in retinal ganglion cells
@en
Serine racemase deletion aboli ...... ents in retinal ganglion cells
@nl
prefLabel
Serine racemase deletion aboli ...... ents in retinal ganglion cells
@en
Serine racemase deletion aboli ...... ents in retinal ganglion cells
@nl
P2093
P2860
P1476
Serine racemase deletion aboli ...... ents in retinal ganglion cells
@en
P2093
Joseph T Coyle
Manuel Esguerra
Robert F Miller
Robert J Wickham
Steve J Sullivan
P2860
P304
P356
10.1113/JPHYSIOL.2011.217059
P407
P577
2011-10-31T00:00:00Z