Dissecting carbohydrate–Cyanovirin-N binding by structure-guided mutagenesis: functional implications for viral entry inhibition
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The Novel Fold of Scytovirin Reveals a New Twist For Antiviral Entry InhibitorsConformational gating of dimannose binding to the antiviral protein cyanovirin revealed from the crystal structure at 1.35 Å resolutionSolution and Crystal Structures of a Sugar Binding Site Mutant of Cyanovirin-N: No Evidence of Domain SwappingA designed chimeric cyanovirin-N homolog lectin: Structure and molecular basis of sucrose bindingAnti-HIV Activity of Defective Cyanovirin-N Mutants Is Restored by DimerizationNMR solution structure of a cyanovirin homolog from wheat head blight fungusStructural Insights into the Anti-HIV Activity of the Oscillatoria agardhii Agglutinin Homolog Lectin FamilyDesigned oligomers of cyanovirin-N show enhanced HIV neutralizationStructural Basis of the Anti-HIV Activity of the Cyanobacterial Oscillatoria Agardhii AgglutininDifferent 3D domain-swapped oligomeric cyanovirin-N structures suggest trapped folding intermediatesInvestigation of griffithsin's interactions with human cells confirms its outstanding safety and efficacy profile as a microbicide candidateA flexible docking scheme efficiently captures the energetics of glycan-cyanovirin binding.Broad anti-HIV activity of the Oscillatoria agardhii agglutinin homologue lectin family.Longer simulations sample larger subspaces of conformations while maintaining robust mechanisms of motionSweet entanglements--protein:glycan interactions in two HIV-inactivating lectin familiesA Designed "Nested" Dimer of Cyanovirin-N Increases Antiviral Activity.Fluorinated carbohydrates as lectin ligands: dissecting glycan-cyanovirin interactions by using 19F NMR spectroscopy.Linker-extended native cyanovirin-N facilitates PEGylation and potently inhibits HIV-1 by targeting the glycan ligand.The antiviral lectin cyanovirin-N: probing multivalency and glycan recognition through experimental and computational approaches.Polymeric anti-HIV therapeutics.Structure and Glycan Binding of a New Cyanovirin-N Homolog.Rational and computational design of stabilized variants of cyanovirin-N that retain affinity and specificity for glycan ligands.Antiviral lectins: Selective inhibitors of viral entry.Solution and crystal molecular dynamics simulation study of m4-cyanovirin-N mutants complexed with di-mannose.An update of the recombinant protein expression systems of Cyanovirin-N and challenges of preclinical development.
P2860
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P2860
Dissecting carbohydrate–Cyanovirin-N binding by structure-guided mutagenesis: functional implications for viral entry inhibition
description
wetenschappelijk artikel
@nl
наукова стаття, опублікована у вересні 2006
@uk
name
Dissecting carbohydrate–Cyanov ...... ons for viral entry inhibition
@en
Dissecting carbohydrate–Cyanov ...... ons for viral entry inhibition
@nl
type
label
Dissecting carbohydrate–Cyanov ...... ons for viral entry inhibition
@en
Dissecting carbohydrate–Cyanov ...... ons for viral entry inhibition
@nl
prefLabel
Dissecting carbohydrate–Cyanov ...... ons for viral entry inhibition
@en
Dissecting carbohydrate–Cyanov ...... ons for viral entry inhibition
@nl
P2093
P356
P1476
Dissecting carbohydrate–Cyanov ...... ons for viral entry inhibition
@en
P2093
Elena Matei
Fátima Lasala
Laura G. Barrientos
Rafael Delgado
P304
P356
10.1093/PROTEIN/GZL040
P577
2006-09-29T00:00:00Z