The Effect of Parkinson's-Disease-Associated Mutations on the Deubiquitinating Enzyme UCH-L1
about
Ubiquitin C-terminal hydrolase L1 (UCH-L1): structure, distribution and roles in brain function and dysfunctionProtein knotting through concatenation significantly reduces folding stabilityFolding analysis of the most complex Stevedore's protein knotUbiquitin carboxyl-terminal esterase L1 (UCHL1) is associated with stem-like cancer cell functions in pediatric high-grade gliomaUCHL1 S18Y variant is a risk factor for Parkinson's disease in Japan.Dynamic changes of the phosphoproteome in postmortem mouse brains.Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-lifeThe ubiquitin C-terminal hydrolase L1 (UCH-L1) C terminus plays a key role in protein stability, but its farnesylation is not required for membrane association in primary neurons.Transient sampling of aggregation-prone conformations causes pathogenic instability of a parkinsonian mutant of DJ-1 at physiological temperature.Increased generation of cyclopentenone prostaglandins after brain ischemia and their role in aggregation of ubiquitinated proteins in neuronsKnotting and unknotting of a protein in single molecule experiments.Entropic stabilization of a deubiquitinase provides conformational plasticity and slow unfolding kinetics beneficial for functioning on the proteasomeProteostasis and movement disorders: Parkinson's disease and amyotrophic lateral sclerosis.Method for measuring the activity of deubiquitinating enzymes in cell lines and tissue samples.Chronic phencyclidine increases synapsin-1 and synaptic adaptation proteins in the medial prefrontal cortex.Characterization of the Folding of a 52-Knotted Protein Using Engineered Single-Tryptophan Variants.Lactose Binding Induces Opposing Dynamics Changes in Human Galectins Revealed by NMR-Based Hydrogen-Deuterium Exchange.The exclusive effects of chaperonin on the behavior of proteins with 52 knot.Topologically knotted deubiquitinases exhibit unprecedented mechanostability to withstand the proteolysis by an AAA+ protease.
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P2860
The Effect of Parkinson's-Disease-Associated Mutations on the Deubiquitinating Enzyme UCH-L1
description
article
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im März 2011 veröffentlichter wissenschaftlicher Artikel
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wetenschappelijk artikel
@nl
наукова стаття, опублікована в березні 2011
@uk
name
The Effect of Parkinson's-Dise ...... Deubiquitinating Enzyme UCH-L1
@en
The Effect of Parkinson's-Dise ...... Deubiquitinating Enzyme UCH-L1
@nl
type
label
The Effect of Parkinson's-Dise ...... Deubiquitinating Enzyme UCH-L1
@en
The Effect of Parkinson's-Dise ...... Deubiquitinating Enzyme UCH-L1
@nl
prefLabel
The Effect of Parkinson's-Dise ...... Deubiquitinating Enzyme UCH-L1
@en
The Effect of Parkinson's-Dise ...... Deubiquitinating Enzyme UCH-L1
@nl
P2093
P1476
The Effect of Parkinson's-Dise ...... Deubiquitinating Enzyme UCH-L1
@en
P2093
Chittarnajan Das
Elizabeth F. Werrell
Fredrik I. Andersson
Lindsay McMorran
Sophie E. Jackson
William J.K. Crone
P304
P356
10.1016/J.JMB.2010.12.029
P407
P577
2011-03-01T00:00:00Z