Up-Regulation of Rho/ROCK Signaling in Sarcoma Cells Drives Invasion and Increased Generation of Protrusive Forces
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Cellular traction stresses increase with increasing metastatic potentialValidation of the effects of TGF-β1 on tumor recurrence and prognosis through tumor retrieval and cell mechanical propertiesLIM kinase1 modulates function of membrane type matrix metalloproteinase 1: implication in invasion of prostate cancer cellsCell polarity signaling in the plasticity of cancer cell invasivenessPhysical view on migration modesReduced expression of the ROCK inhibitor Rnd3 is associated with increased invasiveness and metastatic potential in mesenchymal tumor cellsThe actin targeting compound Chondramide inhibits breast cancer metastasis via reduction of cellular contractilityThe role of focal adhesion anchoring domains of CAS in mechanotransduction.Integrin α5β1 facilitates cancer cell invasion through enhanced contractile forces.Vincristine enhances amoeboid-like motility via GEF-H1/RhoA/ROCK/Myosin light chain signaling in MKN45 cellsAn in vitro correlation of mechanical forces and metastatic capacity.Dynamic regulation of ROCK in tumor cells controls CXCR4-driven adhesion eventsDifferential expressions of adhesive molecules and proteases define mechanisms of ovarian tumor cell matrix penetration/invasion.The effect of ROCK-1 activity change on the adhesive and invasive ability of Y79 retinoblastoma cellsPolyacrylamide gels for invadopodia and traction force assays on cancer cells.Contractile forces contribute to increased glycosylphosphatidylinositol-anchored receptor CD24-facilitated cancer cell invasion.PKCα promotes the mesenchymal to amoeboid transition and increases cancer cell invasiveness.Mechanobiology of tumor invasion: engineering meets oncology.Expression of Wnt11 and Rock2 protein with clinical characteristics of esophageal squamous cell carcinoma in Kazakh and Han patientsLKB1 kinase-dependent and -independent defects disrupt polarity and adhesion signaling to drive collagen remodeling during invasion.The molecular mechanisms of transition between mesenchymal and amoeboid invasiveness in tumor cells.Combining mechanical and optical approaches to dissect cellular mechanobiology.Cellular traction stresses mediate extracellular matrix degradation by invadopodiaO-GlcNAcylation promotes migration and invasion in human ovarian cancer cells via the RhoA/ROCK/MLC pathway.Mechanics rules cell biology.The role of the tissue microenvironment in the regulation of cancer cell motility and invasion.The biomechanical properties of 3d extracellular matrices and embedded cells regulate the invasiveness of cancer cells.Rho-associated coiled-coil kinase (ROCK) signaling and disease.Metastasis review: from bench to bedside.The size-speed-force relationship governs migratory cell response to tumorigenic factors.α-TEA inhibits the growth and motility of human colon cancer cells via targeting RhoA/ROCK signalingSpecific upregulation of RHOA and RAC1 in cancer-associated fibroblasts found at primary tumor and lymph node metastatic sites in breast cancer.Metastasis of aggressive amoeboid sarcoma cells is dependent on Rho/ROCK/MLC signaling.RhoE is frequently down-regulated in hepatocellular carcinoma (HCC) and suppresses HCC invasion through antagonizing the Rho/Rho-kinase/myosin phosphatase target pathway.Sdc1 negatively modulates carcinoma cell motility and invasion.Somatic mutation in the ACK1 ubiquitin association domain enhances oncogenic signaling through EGFR regulation in renal cancer derived cells.Multiple roles for RhoA during T cell transendothelial migrationFUS-CHOP Promotes Invasion in Myxoid Liposarcoma through a SRC/FAK/RHO/ROCK-Dependent Pathway.Downregulation of lumican accelerates lung cancer cell invasion through p120 catenin.Bone marrow-derived mesenchymal stem cells promote invasiveness and transendothelial migration of osteosarcoma cells via a mesenchymal to amoeboid transition.
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P2860
Up-Regulation of Rho/ROCK Signaling in Sarcoma Cells Drives Invasion and Increased Generation of Protrusive Forces
description
im September 2008 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published on 01 September 2008
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована у вересні 2008
@uk
name
Up-Regulation of Rho/ROCK Sign ...... eneration of Protrusive Forces
@en
Up-Regulation of Rho/ROCK Sign ...... eneration of Protrusive Forces
@nl
type
label
Up-Regulation of Rho/ROCK Sign ...... eneration of Protrusive Forces
@en
Up-Regulation of Rho/ROCK Sign ...... eneration of Protrusive Forces
@nl
prefLabel
Up-Regulation of Rho/ROCK Sign ...... eneration of Protrusive Forces
@en
Up-Regulation of Rho/ROCK Sign ...... eneration of Protrusive Forces
@nl
P2093
P50
P1476
Up-regulation of Rho/ROCK sign ...... eneration of protrusive forces
@en
P2093
Carina Raupach
Daniel P Zitterbart
Daniela Panková
Krisýtyna Bicanová
Ondrej Tolde
P304
P356
10.1158/1541-7786.MCR-07-2174
P577
2008-09-01T00:00:00Z