Alterations of ubiquitin ligases in human cancer and their association with the natural history of the tumor
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The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosomeStructure-Based Design of Covalent Siah InhibitorsDNA damage induces down-regulation of Prp19 via impairing Prp19 stability in hepatocellular carcinoma cellsTissue biomarkers of breast cancer and their association with conventional pathologic features.Siah1 proteins enhance radiosensitivity of human breast cancer cellsMolecular analysis of ex-vivo CD133+ GBM cells revealed a common invasive and angiogenic profile but different proliferative signatures among high grade gliomas.An atlas of altered expression of deubiquitinating enzymes in human cancerDeficiency in the 15-kDa selenoprotein inhibits tumorigenicity and metastasis of colon cancer cells.Abrogation of junctional adhesion molecule-A expression induces cell apoptosis and reduces breast cancer progression.Proteomic profiling of human respiratory epithelia by iTRAQ reveals biomarkers of exposure and harm by tobacco smoke components.Investigating the molecular basis of Siah1 and Siah2 E3 ubiquitin ligase substrate specificity.HUWE1 is a molecular link controlling RAF-1 activity supported by the Shoc2 scaffold.Quantitative Lys-ϵ-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1.Progression from cirrhosis to cancer is associated with early ubiquitin post-translational modifications: identification of new biomarkers of cirrhosis at risk of malignancy.An insulator element located at the cyclin B1 interacting protein 1 gene locus is highly conserved among mammalian species.The Expression of the Ubiquitin Ligase SIAH2 (Seven In Absentia Homolog 2) Is Increased in Human Lung Cancer.SIAH2 protein expression in breast cancer is inversely related with ER status and outcome to tamoxifen therapyMule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15The function of Shoc2: A scaffold and beyond.Prp19 facilitates invasion of hepatocellular carcinoma via p38 mitogen-activated protein kinase/twist1 pathway.The fragile X protein binds mRNAs involved in cancer progression and modulates metastasis formation.SIAH and EGFR, Two RAS Pathway Biomarkers, are Highly Prognostic in Locally Advanced and Metastatic Breast CancerStress-induced changes in gene interactions in human cells.E3 ubiquitin ligase Mule targets β-catenin under conditions of hyperactive Wnt signaling.New insights into pre-mRNA processing factor 19: A multi-faceted protein in humans.Role of E3 ubiquitin ligases in lung cancer.Screening for E3-ubiquitin ligase inhibitors: challenges and opportunities.Tumour suppressive function of HUWE1 in thyroid cancer.HUWE1 interacts with PCNA to alleviate replication stress.SIAH ubiquitin ligases regulate breast cancer cell migration and invasion independent of the oxygen status.miR-135a leads to cervical cancer cell transformation through regulation of β-catenin via a SIAH1-dependent ubiquitin proteosomal pathway.Network-based identification of key proteins involved in apoptosis and cell cycle regulation.HUWE1 ubiquitylates and degrades the RAC activator TIAM1 promoting cell-cell adhesion disassembly, migration, and invasion.A conformational switch regulates the ubiquitin ligase HUWE1.Memo is a copper-dependent redox protein with an essential role in migration and metastasis.Plasma-derived extracellular vesicle proteins as a source of biomarkers for lung adenocarcinoma.SNORD126 promotes HCC and CRC cell growth by activating the PI3K-AKT pathway through FGFR2.Epigenetic therapy: targeting histones and their modifications in human disease.Ubiquitination by HUWE1 in tumorigenesis and beyond
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Alterations of ubiquitin ligases in human cancer and their association with the natural history of the tumor
description
im Juni 2009 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published on 22 June 2009
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wetenschappelijk artikel
@nl
наукова стаття, опублікована в червні 2009
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name
Alterations of ubiquitin ligas ...... e natural history of the tumor
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Alterations of ubiquitin ligas ...... e natural history of the tumor
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type
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Alterations of ubiquitin ligas ...... e natural history of the tumor
@en
Alterations of ubiquitin ligas ...... e natural history of the tumor
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prefLabel
Alterations of ubiquitin ligas ...... e natural history of the tumor
@en
Alterations of ubiquitin ligas ...... e natural history of the tumor
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P2093
P2860
P50
P356
P1433
P1476
Alterations of ubiquitin ligas ...... e natural history of the tumor
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P2093
M Donzelli
P P Di Fiore
P2860
P2888
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P356
10.1038/ONC.2009.156
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P577
2009-06-22T00:00:00Z