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The Differentiation of CD4(+) T-Helper Cell Subsets in the Context of Helminth Parasite InfectionConcerted activity of IgG1 antibodies and IL-4/IL-25-dependent effector cells trap helminth larvae in the tissues following vaccination with defined secreted antigens, providing sterile immunity to challenge infectionCutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cellsThe role of CTLA-4 in the regulation of T cell immune responses.Annotated mitochondrial genome with Nanopore R9 signal for Nippostrongylus brasiliensis.Secreted proteomes of different developmental stages of the gastrointestinal nematode Nippostrongylus brasiliensisMacrophage-derived human resistin is induced in multiple helminth infections and promotes inflammatory monocytes and increased parasite burden.CD8+ T cells and immunoregulatory networks in asthma.Antibodies and IL-3 support helminth-induced basophil expansion.Mechanistic studies of copper(I)-catalyzed 1,3-halogen migrationEpigenetic regulation of Th2 cytokine expression in atopic diseases.Bystander suppression of allergic airway inflammation by lung resident memory CD8+ T cells.Dermal group 2 innate lymphoid cells in atopic dermatitis and allergy.ILC2s and T cells cooperate to ensure maintenance of M2 macrophages for lung immunity against hookworms.Absence of airway inflammation in a large proportion of adolescents with asthma.CD326(lo)CD103(lo)CD11b(lo) dermal dendritic cells are activated by thymic stromal lymphopoietin during contact sensitization in mice.The role of ILC2 in hookworm infection.Mucosal trapping and degradation of Nippostrongylus brasiliensis occurs in the absence of STAT6.Lifelong farm exposure may strongly reduce the risk of asthma in adults.T cell-derived IL-3 plays key role in parasite infection-induced basophil production but is dispensable for in vivo basophil survival.IL-4 Haploinsufficiency Specifically Impairs IgE Responses against Allergens in Mice.Farm exposure in utero may protect against asthma, hay fever and eczema.Immature murine NKT cells pass through a stage of developmentally programmed innate IL-4 secretion.Can bacterial endotoxin exposure reverse atopy and atopic disease?Non-cytotoxic, IL-4, IL-5, IL-10 producing CD8+ T cells: their activation and effector functions.Switch of CD8 T cells to noncytolytic CD8-CD4- cells that make TH2 cytokines and help B cells.Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) can regulate dendritic cell-induced activation and cytotoxicity of CD8(+) T cells independently of CD4(+) T cell help.CD80 costimulation is essential for the induction of airway eosinophiliaIL-4 Derived from Non-T Cells Induces Basophil- and IL-3-independent Th2 Immune Responses.IL-4 differentiates naive CD8+ T cells to a "Th2-like" phenotype: a link between viral infections and bronchial asthma.Activation of p38 MAP kinase in T cells facilitates the immune response to the influenza virus.Helminth-conditioned dendritic cells prime CD4+ T cells to IL-4 production in vivo.IL-25 exhibits disparate roles during Th2-cell differentiation versus effector function.Toll-Like Receptor 4, but Not Neutrophil Extracellular Traps, Promote IFN Type I Expression to Enhance Th2 Responses to Nippostrongylus brasiliensis.De novo assembly of the complex genome of Nippostrongylus brasiliensis using MinION long reads.Tissue localization and frequency of antigen-specific effector CD4 T cells determines the development of allergic airway inflammation.Secretory products from infective forms of Nippostrongylus brasiliensis induce a rapid allergic airway inflammatory response.Allergic airway inflammation is exacerbated during acute influenza infection and correlates with increased allergen presentation and recruitment of allergen-specific T-helper type 2 cells.The Study of Host Immune Responses Elicited by the Model Murine Hookworms Nippostrongylus brasiliensis and Heligmosomoides polygyrus.Evaluating the in vivo Th2 priming potential among common allergens.
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description
researcher, ORCID id # 0000-0002-5721-0442
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wetenschapper
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name
Graham Le Gros
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Graham Le Gros
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Graham Le Gros
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Graham Le Gros
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Graham Le Gros
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Graham Le Gros
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Graham Le Gros
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Graham Le Gros
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prefLabel
Graham Le Gros
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Graham Le Gros
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Graham Le Gros
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Graham Le Gros
@nl
P108
P106
P1153
7005876876
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P496
0000-0002-5721-0442