Two distinct molecular subtypes of chronic lymphocytic leukemia give new insights on the pathogenesis of the disease and identify novel therapeutic targets

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Two distinct molecular subtypes of chronic lymphocytic leukemia give new insights on the pathogenesis of the disease and identify novel therapeutic targets

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im Mai 2015 veröffentlichter wissenschaftlicher Artikel

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scientific article published on 12 May 2015

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wetenschappelijk artikel

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наукова стаття, опублікована в травні 2015

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Two distinct molecular subtype ...... tify novel therapeutic targets

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Two distinct molecular subtype ...... tify novel therapeutic targets

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Two distinct molecular subtype ...... tify novel therapeutic targets

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Two distinct molecular subtype ...... tify novel therapeutic targets

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Two distinct molecular subtype ...... tify novel therapeutic targets

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Two distinct molecular subtype ...... tify novel therapeutic targets

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P1476

Two distinct molecular subtype ...... tify novel therapeutic targets

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P2093

Antonia Rodriguez

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Beatriz Herreros

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Elena Domenech

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Jose Garcia-Marco

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Juan-F Garcia

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Pilar Llamas

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Raul Cordoba

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P2860

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy

Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia

Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures

Controlling the false discovery rate in behavior genetics research

Next station in microarray data analysis: GEPAS.

Babelomics: an integrative platform for the analysis of transcriptomics, proteomics and genomic data with advanced functional profiling.

Chronic lymphocytic leukemia cells in a lymph node microenvironment depict molecular signature associated with an aggressive disease.

A hierarchical unsupervised growing neural network for clustering gene expression patterns.

Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765.

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134-142

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scholarly article

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10.3109/10428194.2015.1034706

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P433

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P478

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Miguel A. Piris

Joaquin Martinez-Lopez

M Sánchez-Beato

A García-Raso

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2015-05-12T00:00:00Z

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P698

25811675

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P921

leukemia