Localization of an Insulin-like Growth Factor (IGF) Binding Site of Bovine IGF Binding Protein-2 Using Disulfide Mapping and Deletion Mutation Analysis of the C-terminal Domain
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Substitutions for hydrophobic amino acids in the N-terminal domains of IGFBP-3 and -5 markedly reduce IGF-I binding and alter their biologic actionsInsulin-like growth factor system in cancer: novel targeted therapiesThe N-terminal disulfide linkages of human insulin-like growth factor-binding protein-6 (hIGFBP-6) and hIGFBP-1 are different as determined by mass spectrometryInsulin-like growth factor-binding protein 5 complexes with the acid-labile subunit. Role of the carboxyl-terminal domainIsolation and characterization of circulating 13-kDa C-terminal fragments of human insulin-like growth factor binding protein-5O-glycosylation of insulin-like growth factor (IGF) binding protein-6 maintains high IGF-II binding affinity by decreasing binding to glycosaminoglycans and susceptibility to proteolysisSpecific amino acid substitutions determine the differential contribution of the N- and C-terminal domains of insulin-like growth factor (IGF)-binding protein-5 in binding IGF-I.Exogenous administration of protease-resistant, non-matrix-binding IGFBP-2 inhibits tumour growth in a murine model of breast cancer.Insulin-like growth factor binding proteins (IGFBPs) as potential physiological substrates for human kallikreins hK2 and hK3.Defining the disulfide bonds of insulin-like growth factor-binding protein-5 by tandem mass spectrometry with electron transfer dissociation and collision-induced dissociation.IGFBP-2 - taking the lead in growth, metabolism and cancerBIAcore analysis of bovine insulin-like growth factor (IGF)-binding protein-2 identifies major IGF binding site determinants in both the amino- and carboxyl-terminal domains.Role of N- and C-terminal residues of insulin-like growth factor (IGF)-binding protein-3 in regulating IGF complex formation and receptor activation.Insulin-like growth factor binding protein-2 (IGFBP-2) in Japanese flounder, Paralichthys olivaceus: molecular cloning, expression patterns and hormonal regulation during metamorphosis.Contribution of residues A54 and L55 of the human insulin-like growth factor-II (IGF-II) A domain to Type 2 IGF receptor binding specificity.Structure and properties of the C-terminal domain of insulin-like growth factor-binding protein-1 isolated from human amniotic fluid.Binding site for the C-domain of insulin-like growth factor (IGF) binding protein-6 on IGF-II; implications for inhibition of IGF actions.Alanine screening mutagenesis establishes tyrosine 60 of bovine insulin-like growth factor binding protein-2 as a determinant of insulin-like growth factor binding.
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P2860
Localization of an Insulin-like Growth Factor (IGF) Binding Site of Bovine IGF Binding Protein-2 Using Disulfide Mapping and Deletion Mutation Analysis of the C-terminal Domain
description
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
im Februar 1998 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published in Journal of Biological Chemistry
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в лютому 1998
@uk
name
Localization of an Insulin-lik ...... lysis of the C-terminal Domain
@en
Localization of an Insulin-like Growth Factor
@nl
type
label
Localization of an Insulin-lik ...... lysis of the C-terminal Domain
@en
Localization of an Insulin-like Growth Factor
@nl
prefLabel
Localization of an Insulin-lik ...... lysis of the C-terminal Domain
@en
Localization of an Insulin-like Growth Factor
@nl
P2093
P2860
P356
P1476
Localization of an insulin-lik ...... lysis of the C-terminal domain
@en
P2093
P2860
P304
P356
10.1074/JBC.273.8.4647
P407
P577
1998-02-01T00:00:00Z