Constitutive activation of Stat5 promotes its cytoplasmic localization and association with PI3-kinase in myeloid leukemias
about
Function, regulation and pathological roles of the Gab/DOS docking proteinsGAB2--a scaffolding protein in cancerProtein tyrosine phosphatases as wardens of STAT signalingInhibition of STAT5: a therapeutic option in BCR-ABL1-driven leukemiaThe role of the JAK-STAT pathway and related signal cascades in telomerase activation during the development of hematologic malignanciesSTAT5 in hematopoietic stem cell biology and transplantationPAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesisBCR-ABL affects STAT5A and STAT5B differentiallySNP array karyotyping allows for the detection of uniparental disomy and cryptic chromosomal abnormalities in MDS/MPD-U and MPD.MegakaryopoiesisCombination treatment for myeloproliferative neoplasms using JAK and pan-class I PI3K inhibitors.Integrated genomic sequencing reveals mutational landscape of T-cell prolymphocytic leukemiaStat5a serine 725 and 779 phosphorylation is a prerequisite for hematopoietic transformationDifferential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival.The different functions of Stat5 and chromatin alteration through Stat5 proteinsMolecular targets for the treatment of juvenile myelomonocytic leukemia.Novel mechanism for Fc{epsilon}RI-mediated signal transducer and activator of transcription 5 (STAT5) tyrosine phosphorylation and the selective influence of STAT5B over mast cell cytokine production.STAT5 gene polymorphisms are associated with the response of acute myeloid leukemia patients to Ara-C-based chemotherapy.Signal transducer and activator of transcription 5b (Stat5b) serine 193 is a novel cytokine-induced phospho-regulatory site that is constitutively activated in primary hematopoietic malignancies.Structure, regulation, signaling, and targeting of abl kinases in cancer.IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survivalThe Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenesDistinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1.Stat5 as a diagnostic marker for leukemia.Signal interception-based therapies--a double-edged sword in Bcr/abl-induced malignancies?Targeting signal transducer and activator of transcription signaling pathway in leukemias.Expression of activated STAT5 in neoplastic mast cells in systemic mastocytosis: subcellular distribution and role of the transforming oncoprotein KIT D816V.STAT3 transcription factor is constitutively activated and is oncogenic in nasal-type NK/T-cell lymphoma.The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo.Molecular pathogenesis of Waldenstrom's macroglobulinemia.STAT5-mediated self-renewal of normal hematopoietic and leukemic stem cells.Oxidative metabolism in cancer: A STAT affair?Co-operating STAT5 and AKT signaling pathways in chronic myeloid leukemia and mastocytosis: possible new targets of therapy.STAT3 Inhibition Induces Apoptosis in Cancer Cells Independent of STAT1 or STAT2.Synergistic cell death in FLT3-ITD positive acute myeloid leukemia by combined treatment with metformin and 6-benzylthioinosine.A rapid method for quantifying cytoplasmic versus nuclear localization in endogenous peripheral blood leukocytes by conventional flow cytometry.Angiotensin II Receptor Blockers Attenuate Lipopolysaccharide-Induced Memory Impairment by Modulation of NF-κB-Mediated BDNF/CREB Expression and Apoptosis in Spontaneously Hypertensive Rats.O-GlcNAcylation of STAT5 controls tyrosine phosphorylation and oncogenic transcription in STAT5-dependent malignancies.Evidence for a protective role of the STAT5 transcription factor against oxidative stress in human leukemic pre-B cells.Oncogenic STAT5 signaling promotes oxidative stress in chronic myeloid leukemia cells by repressing antioxidant defenses.
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Constitutive activation of Stat5 promotes its cytoplasmic localization and association with PI3-kinase in myeloid leukemias
description
im Februar 2007 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published on 12 October 2006
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в лютому 2007
@uk
name
Constitutive activation of Sta ...... I3-kinase in myeloid leukemias
@en
Constitutive activation of Sta ...... I3-kinase in myeloid leukemias
@nl
type
label
Constitutive activation of Sta ...... I3-kinase in myeloid leukemias
@en
Constitutive activation of Sta ...... I3-kinase in myeloid leukemias
@nl
prefLabel
Constitutive activation of Sta ...... I3-kinase in myeloid leukemias
@en
Constitutive activation of Sta ...... I3-kinase in myeloid leukemias
@nl
P2093
P50
P1433
P1476
Constitutive activation of Sta ...... I3-kinase in myeloid leukemias
@en
P2093
Christian Pecquet
Fabrice Gouilleux
Hartmut Beug
Isabelle Dhennin
Kaiss Lassoued
Karoline Sonneck
Marc Kerenyi
Noria Harir
Valerie Gouilleux-Gruart
P304
P356
10.1182/BLOOD-2006-01-029918
P407
P577
2006-10-12T00:00:00Z