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A new variant of the Ntn hydrolase fold revealed by the crystal structure of L-aminopeptidase D-ala-esterase/amidase from Ochrobactrum anthropiCrystal structure of a D-aminopeptidase from Ochrobactrum anthropi, a new member of the 'penicillin-recognizing enzyme' familyCrystal structures of a psychrophilic metalloprotease reveal new insights into catalysis by cold-adapted proteasesCrystal structures of two Bordetella pertussis periplasmic receptors contribute to defining a novel pyroglutamic acid binding DctP subfamilyStructure-based mechanism of ligand binding for periplasmic solute-binding protein of the Bug familyX-ray structure of papaya chitinase reveals the substrate binding mode of glycosyl hydrolase family 19 chitinasesSynthetic EthR inhibitors boost antituberculous activity of ethionamideExploring drug target flexibility using in situ click chemistry: application to a mycobacterial transcriptional regulatorPeriplasmic domain of the sensor-kinase BvgS reveals a new paradigm for the Venus flytrap mechanismFunctional importance of a conserved sequence motif in FhaC, a prototypic member of the TpsB/Omp85 superfamilyNMR structure of the human Mediator MED25 ACID domainStructural insights into ChpT, an essential dimeric histidine phosphotransferase regulating the cell cycle inCaulobacter crescentusEthionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1,2,4-oxadiazole EthR inhibitorsStructural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligandsStructure of the secretion domain of HxuA fromHaemophilus influenzaeDiscovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesisLigand efficiency driven design of new inhibitors of Mycobacterium tuberculosis transcriptional repressor EthR using fragment growing, merging, and linking approachesCrystal structure of Pseudomonas aeruginosa catabolic ornithine transcarbamoylase at 3.0-A resolution: a different oligomeric organization in the transcarbamoylase familyCrystal structure of spinach chloroplast fructose-1,6-bisphosphatase at 2.8 A resolutionStructural aspects of the allosteric inhibition of fructose-1,6-bisphosphatase by AMP: the binding of both the substrate analogue 2,5-anhydro-D-glucitol 1,6-bisphosphate and catalytic metal ions monitored by X-ray crystallographyThe crystal structure of Pyrococcus furiosus ornithine carbamoyltransferase reveals a key role for oligomerization in enzyme stability at extremely high temperaturesDNA binding of the cell cycle transcriptional regulator GcrA depends on N6-adenosine methylation in Caulobacter crescentus and other AlphaproteobacteriaCharacterization of ERM transactivation domain binding to the ACID/PTOV domain of the Mediator subunit MED25Conserved Omp85 lid-lock structure and substrate recognition in FhaCProbing the conformation of FhaC with small-angle neutron scattering and molecular modeling.Substrate recognition by the POTRA domains of TpsB transporter FhaC.First structural insights into the TpsB/Omp85 superfamily.Structure of the membrane protein FhaC: a member of the Omp85-TpsB transporter superfamily.Crystal structure of Bordetella pertussis BugD solute receptor unveils the basis of ligand binding in a new family of periplasmic binding proteins.The level of Ets-1 protein is regulated by poly(ADP-ribose) polymerase-1 (PARP-1) in cancer cells to prevent DNA damage.A Salmonella type three secretion effector/chaperone complex adopts a hexameric ring-like structure.Virulence regulation with Venus flytrap domains: structure and function of the periplasmic moiety of the sensor-kinase BvgSInsights into mechanisms of induction and ligands recognition in the transcriptional repressor EthR from Mycobacterium tuberculosis.Crystallization and preliminary X-ray diffraction analysis of two extracytoplasmic solute receptors of the DctP family from Bordetella pertussis.Crystallization and preliminary X-ray analysis of a family 19 glycosyl hydrolase from Carica papaya latex.Crystallization and preliminary X-ray diffraction analysis of the peptidylprolyl isomerase Par27 of Bordetella pertussisThe crystal structure of filamentous hemagglutinin secretion domain and its implications for the two-partner secretion pathway.Aspartate carbamoyltransferase from the thermoacidophilic archaeon Sulfolobus acidocaldarius. Cloning, sequence analysis, enzyme purification and characterization.Crystallization and preliminary X-ray diffraction studies of the glutaminyl cyclase from Carica papaya latex.The Mediator complex subunit MED25 is targeted by the N-terminal transactivation domain of the PEA3 group members
P50
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P50
description
onderzoeker
@nl
researcher, ORCID id # 0000-0003-4504-056X
@en
name
Vincent Villeret
@ast
Vincent Villeret
@en
Vincent Villeret
@es
Vincent Villeret
@nl
type
label
Vincent Villeret
@ast
Vincent Villeret
@en
Vincent Villeret
@es
Vincent Villeret
@nl
prefLabel
Vincent Villeret
@ast
Vincent Villeret
@en
Vincent Villeret
@es
Vincent Villeret
@nl
P106
P31
P496
0000-0003-4504-056X