Calmodulin and Munc13 Form a Ca2+ Sensor/Effector Complex that Controls Short-Term Synaptic Plasticity
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Neurotransmitter release: the last millisecond in the life of a synaptic vesicleThe presynaptic active zoneSynaptic vesicle exocytosisCalmodulin suppresses synaptotagmin-2 transcription in cortical neuronsMunc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosisELKS2alpha/CAST deletion selectively increases neurotransmitter release at inhibitory synapsesStructural basis for a Munc13-1 homodimer to Munc13-1/RIM heterodimer switchMolecular Machines Regulating the Release Probability of Synaptic Vesicles at the Active ZoneRegeneration, Plasticity, and Induced Molecular Programs in Adult Zebrafish BrainSustaining rapid vesicular release at active zones: potential roles for vesicle tetheringDistinct initial SNARE configurations underlying the diversity of exocytosisDocking of LDCVs is modulated by lower intracellular [Ca2+] than primingModular architecture of Munc13/calmodulin complexes: dual regulation by Ca2+ and possible function in short-term synaptic plasticityAberrant morphology and residual transmitter release at the Munc13-deficient mouse neuromuscular synapseMunc13-like skMLCK variants cannot mimic the unique calmodulin binding mode of Munc13 as evidenced by chemical cross-linking and mass spectrometryNonconserved Ca(2+)/calmodulin binding sites in Munc13s differentially control synaptic short-term plasticity.Myosin-Va regulates exocytosis through the submicromolar Ca2+-dependent binding of syntaxin-1A.Munc13-1 is required for presynaptic long-term potentiationPresynaptic Calmodulin targets: lessons from structural proteomics.Superpriming of synaptic vesicles as a common basis for intersynapse variability and modulation of synaptic strength.Munc18-1 is a dynamically regulated PKC target during short-term enhancement of transmitter releaseShort-term facilitation modulates size and timing of the synaptic response at the inner hair cell ribbon synapse.Relative roles of different mechanisms of depression at the mouse endbulb of Held.Synaptic UNC13A protein variant causes increased neurotransmission and dyskinetic movement disorderMunc13-4 functions as a Ca2+ sensor for homotypic secretory granule fusion to generate endosomal exocytic vacuoles.Exome sequencing for bipolar disorder points to roles of de novo loss-of-function and protein-altering mutations.Heterodimerization of Munc13 C2A domain with RIM regulates synaptic vesicle docking and priming.Scanning the human proteome for calmodulin-binding proteins.Single-molecule studies of the neuronal SNARE fusion machinery.Protein kinase C is a calcium sensor for presynaptic short-term plasticity.DOC2B and Munc13-1 differentially regulate neuronal network activity.Calmodulin enhances ribbon replenishment and shapes filtering of synaptic transmission by cone photoreceptorsStudying synaptic efficiency by post-hoc immunolabelling.A sequential vesicle pool model with a single release sensor and a Ca(2+)-dependent priming catalyst effectively explains Ca(2+)-dependent properties of neurosecretion.Tim50's presequence receptor domain is essential for signal driven transport across the TIM23 complexActive zones for presynaptic plasticity in the brain.Presynaptic active zones in invertebrates and vertebrates.Posttetanic potentiation critically depends on an enhanced Ca(2+) sensitivity of vesicle fusion mediated by presynaptic PKC.Molecular underpinnings of synaptic vesicle pool heterogeneity.Enlightening molecular mechanisms through study of protein interactions
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Calmodulin and Munc13 Form a Ca2+ Sensor/Effector Complex that Controls Short-Term Synaptic Plasticity
description
im August 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published on 01 August 2004
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в серпні 2004
@uk
name
Calmodulin and Munc13 Form a C ...... Short-Term Synaptic Plasticity
@en
Calmodulin and Munc13 Form a C ...... Short-Term Synaptic Plasticity
@nl
type
label
Calmodulin and Munc13 Form a C ...... Short-Term Synaptic Plasticity
@en
Calmodulin and Munc13 Form a C ...... Short-Term Synaptic Plasticity
@nl
prefLabel
Calmodulin and Munc13 Form a C ...... Short-Term Synaptic Plasticity
@en
Calmodulin and Munc13 Form a C ...... Short-Term Synaptic Plasticity
@nl
P2093
P50
P1433
P1476
Calmodulin and Munc13 form a C ...... short-term synaptic plasticity
@en
P2093
Jeong-Seop Rhee
Joachim Spiess
M Neal Waxham
Nils Brose
P304
P356
10.1016/J.CELL.2004.06.029
P407
P577
2004-08-01T00:00:00Z