Extracellular Matrix-derived Peptide Binds to αvβ3Integrin and Inhibits Angiogenesis
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Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrinsPhysiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrinIdentification of amino acids essential for the antiangiogenic activity of tumstatin and its use in combination antitumor activitySelective alpha-particle mediated depletion of tumor vasculature with vascular normalizationMammalian collagen IVThe transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translationTetrastatin, the NC1 domain of the α4(IV) collagen chain: a novel potent anti-tumor matrikine.The anti-tumor properties of two tumstatin peptide fragments in human gastric carcinoma.Antiangiogenic activity of 2-deoxy-D-glucose.Characterization of a non-fibrillar-related collagen in the mollusc Haliotis tuberculata and its biological activity on human dermal fibroblasts.Function of endogenous inhibitors of angiogenesis as endothelium-specific tumor suppressorsAngiogenesis and chronic kidney disease.A novel antiangiogenic peptide derived from hepatocyte growth factor inhibits neovascularization in vitro and in vivo.The potential of nanomedicine therapies to treat neovascular disease in the retina.Regulation of Tumor Angiogenesis and Choroidal Neovascularization by Endogenous Angioinhibitors.Synthetic disulfide-bridged cyclic peptides mimic the anti-angiogenic actions of chondromodulin-I.Click chemistry for (18)F-labeling of RGD peptides and microPET imaging of tumor integrin alphavbeta3 expressionIntegrins and bone metastasis: integrating tumor cell and stromal cell interactions.Arresten, a collagen-derived angiogenesis inhibitor, suppresses invasion of squamous cell carcinoma.Tiny dancers: the integrin-growth factor nexus in angiogenic signaling.New functional roles for non-collagenous domains of basement membrane collagensThe alpha v integrin antagonists as novel anticancer agents: an update.Anti-angiogenic peptides for cancer therapeuticsCounterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific manner.Prolactin/growth hormone-derived antiangiogenic peptides highlight a potential role of tilted peptides in angiogenesis.Comparison of the antiangiogenic activity of modified RGDRGD-endostatin to endostatin delivered by gene transfer in vivo rabbit neovascularization modelPeptides with anticancer use or potential.The diverse roles of integrins and their ligands in angiogenesis.Molecular targets in the inhibition of angiogenesis.Lamstatin--a novel inhibitor of lymphangiogenesis derived from collagen IVEndothelial FAK as a therapeutic target in disease.Corneal angiogenic privilege: angiogenic and antiangiogenic factors in corneal avascularity, vasculogenesis, and wound healing (an American Ophthalmological Society thesis)Exploration of peptide T7 and its derivative as integrin αvβ3-targeted imaging agents.Tumstatin 185-191 increases the sensitivity of non-small cell lung carcinoma cells to cisplatin by blocking proliferation, promoting apoptosis and inhibiting Akt activation.The anti-tumor NC1 domain of collagen XIX inhibits the FAK/ PI3K/Akt/mTOR signaling pathway through αvβ3 integrin interaction.Tumstatin induces apoptosis mediated by Fas signaling pathway in oral squamous cell carcinoma SCC-VII cells.Tumour angiogenesis, vascular biology and enhanced drug delivery.In-vitro and in-vivo assays for angiogenesis-modulating drug discovery and development.The complexities of TGF-β action during mammary and squamous cell carcinogenesis.Inhibition effect of pcDNA-tum-5 on the growth of S180 tumor.
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P2860
Extracellular Matrix-derived Peptide Binds to αvβ3Integrin and Inhibits Angiogenesis
description
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
im Juni 2001 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published in Journal of Biological Chemistry
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в червні 2001
@uk
name
Extracellular Matrix-derived Peptide Binds to αvβ3Integrin and Inhibits Angiogenesis
@en
Extracellular Matrix-derived Peptide Binds to αvβ3Integrin and Inhibits Angiogenesis
@nl
type
label
Extracellular Matrix-derived Peptide Binds to αvβ3Integrin and Inhibits Angiogenesis
@en
Extracellular Matrix-derived Peptide Binds to αvβ3Integrin and Inhibits Angiogenesis
@nl
prefLabel
Extracellular Matrix-derived Peptide Binds to αvβ3Integrin and Inhibits Angiogenesis
@en
Extracellular Matrix-derived Peptide Binds to αvβ3Integrin and Inhibits Angiogenesis
@nl
P2093
P2860
P356
P1476
Extracellular Matrix-derived Peptide Binds to αvβ3Integrin and Inhibits Angiogenesis
@en
P2093
Corinne Reimer
Kathryn A. Holthaus
Mark Manfredi
Mohanraj Dhanabal
Raghu Kalluri
Sergei Barbashov
Surender Kharbanda
Udaya L. Yerramalla
W. Matthew Dickerson
Yohei Maeshima
P2860
P304
31959-31968
P356
10.1074/JBC.M103024200
P407
P577
2001-06-08T00:00:00Z