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Amelioration of type 1 diabetes following treatment of non-obese diabetic mice with INGAP and lisofylline.Islet β-cell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model.Deletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes developmentInhibition of deoxyhypusine synthase enhances islet {beta} cell function and survival in the setting of endoplasmic reticulum stress and type 2 diabetesThe unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice.Noninvasive assessment of pancreatic beta-cell function in vivo with manganese-enhanced magnetic resonance imaging.Peroxisome proliferator-activated receptor gamma activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance of euchromatin structure.Chronic high fat feeding restricts islet mRNA translation initiation independently of ER stress via DNA damage and p53 activation12-lipoxygenase promotes obesity-induced oxidative stress in pancreatic islets.Maintenance of Pdx1 mRNA translation in islet β-cells during the unfolded protein response.Minireview: 12-Lipoxygenase and Islet β-Cell Dysfunction in Diabetes.Deoxyhypusine synthase haploinsufficiency attenuates acute cytokine signaling.Transcriptional activity of the islet β cell factor Pdx1 is augmented by lysine methylation catalyzed by the methyltransferase Set7/9.Elevations in Circulating Methylated and Unmethylated Preproinsulin DNA in New-Onset Type 1 Diabetes.Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cellsLoss of Free Fatty Acid Receptor 2 leads to impaired islet mass and beta cell survival.Detection of islet β-cell death in vivo by multiplex PCR analysis of differentially methylated DNA.Divergent compensatory responses to high-fat diet between C57BL6/J and C57BLKS/J inbred mouse strains.Protective effects of polyamine depletion in mouse models of type 1 diabetes: implications for therapy.Measurement of Differentially Methylated INS DNA Species in Human Serum Samples as a Biomarker of Islet β Cell DeathInhibition of 12/15-Lipoxygenase Protects Against β Cell Oxidative Stress and Glycemic Deterioration in Mouse Models of Type 1 Diabetes.Mouse islet of Langerhans isolation using a combination of purified collagenase and neutral protease.Elevated unmethylated and methylated insulin DNA are unique markers of A+β+ ketosis prone diabetes.Molecular mechanisms of nonalcoholic fatty liver disease: Potential role for 12-lipoxygenase.Hypoglycemia in a Patient With a Polyhormonal Pancreatic Neuroendocrine Tumor With Evidence of Endocrine Progenitors.Immune reconstitution in ART treated, but not untreated HIV infection, is associated with abnormal beta cell function.Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in MiceBiomarkers of islet beta cell stress and death in type 1 diabetesCellular metabolism constrains innate immune responses in early human ontogenyLongitudinal Intravital Imaging of Biosensor-labeled In Situ Islet Beta CellseIF5A inhibition influences T cell dynamics in the pancreatic microenvironment of the humanized mouse model of Type 1 DiabetesAnalysis of serum Hsp90 as a potential biomarker of β cell autoimmunity in type 1 diabetesInterleukin-6 Reduces β-Cell Oxidative Stress by Linking Autophagy With the Antioxidant ResponseResponse to Comment on Sims et al. Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes. Diabetes Care 2019;42:258-264Proinsulin Secretion Is a Persistent Feature of Type 1 DiabetesHypusinated eIF5A is expressed in the pancreas and spleen of individuals with type 1 and type 2 diabetes1,25-Dihydroxyvitamin D3 enhances glucose-stimulated insulin secretion in mouse and human islets: a role for transcriptional regulation of voltage-gated calcium channels by the vitamin D receptorProfiling of RNAs from Human Islet-Derived Exosomes in a Model of Type 1 DiabetesHypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasisA Versatile, Portable Intravital Microscopy Platform for Studying Beta-cell Biology In Vivo
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description
researcher, ORCID id # 0000-0002-5013-6075
@en
wetenschapper
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name
Raghavendra G Mirmira
@ast
Raghavendra G Mirmira
@en
Raghavendra G Mirmira
@nl
type
label
Raghavendra G Mirmira
@ast
Raghavendra G Mirmira
@en
Raghavendra G Mirmira
@nl
prefLabel
Raghavendra G Mirmira
@ast
Raghavendra G Mirmira
@en
Raghavendra G Mirmira
@nl
P108
P106
P31
P496
0000-0002-5013-6075