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A simple and rapid HPLC-MS method for the simultaneous determination of epinephrine, norepinephrine, dopamine and 5-hydroxytryptamine: application to the secretion of bovine chromaffin cell cultures.Enzymes involved in the detoxification of organophosphorus, carbamate and pyrethroid insecticides through hydrolysis.Future applications of phosphotriesterases in the prophylaxis and treatment of organophosporus insecticide and nerve agent poisonings.Genomic and phenotypic alterations of the neuronal-like cells derived from human embryonal carcinoma stem cells (NT2) caused by exposure to organophosphorus compounds paraoxon and mipafox.An integrated approach for detecting embryotoxicity and developmental toxicity of environmental contaminants using in vitro alternative methods.Roles of NTE protein and encoding gene in development and neurodevelopmental toxicity.Specific effect of 5-fluorouracil on alpha-fetoprotein gene expression during the in vitro mouse embryonic stem cell differentiation.Expression of Neuropathy Target Esterase in mouse embryonic stem cells during differentiation.An alternative in vitro method for detecting neuropathic compounds based on acetylcholinesterase inhibition and on inhibition and aging of neuropathy target esterase (NTE).Expression of biomarker genes of differentiation in D3 mouse embryonic stem cells after exposure to different embryotoxicant and non-embryotoxicant model chemicals.Cholinesterase assay by an efficient fixed time endpoint methodInhibition and aging of neuropathy target esterase by the stereoisomers of a phosphoramidate related to methamidophos.Effects of mipafox, paraoxon, chlorpyrifos and its metabolite chlorpyrifos-oxon on the expression of biomarker genes of differentiation in D3 mouse embryonic stem cells.RNA transcripts for the quantification of differentiation allow marked improvements in the performance of embryonic stem cell test (EST).Organophosphorus pesticide chlorpyrifos and its metabolites alter the expression of biomarker genes of differentiation in D3 mouse embryonic stem cells in a comparable way to other model neurodevelopmental toxicants.Cytotoxic effect against 3T3 fibroblasts cells of saffron floral bio-residues extracts.Serum albumins and detoxication of anti-cholinesterase agents.Silencing of PNPLA6, the neuropathy target esterase (NTE) codifying gene, alters neurodifferentiation of human embryonal carcinoma stem cells (NT2).Stereoselective detoxification of chiral sarin and soman analogues by phosphotriesterase.Rabbit serum albumin hydrolyzes the carbamate carbaryl.Copper activation of organophosporus compounds detoxication by chicken serum.Serum albumin is as efficient as paraxonase in the detoxication of paraoxon at toxicologically relevant concentrations.In vivo inhibition by mipafox of soluble and particulate forms of organophosphorus neuropathy target esterase (NTE) in hen sciatic nerve.Stereospecific hydrolysis of a phosphoramidate as a model to understand the role of biotransformation in the neurotoxicity of chiral organophosphorus compounds.Discrimination of carboxylesterases of chicken neural tissue by inhibition with a neuropathic, non-neuropathic organophosphorus compounds and neuropathy promoter.Acetylcholine-hydrolyzing activities in soluble brain fraction: Characterization with reversible and irreversible inhibitors.Functional pathways altered after silencing Pnpla6 (the codifying gene of neuropathy target esterase) in mouse embryonic stem cells under differentiation.Soluble and particulate organophosphorus neuropathy target esterase in brain and sciatic nerve of the hen, cat, rat, and chick.Peripheral nerve soluble esterases are spontaneously reactivated after inhibition by paraoxon: implications for a new definition of neuropathy target esterase.An in vitro approach for demonstrating the critical role of serum albumin in the detoxication of the carbamate carbaryl at in vivo toxicologically relevant concentrations.Interaction between substrates suggests a relationship between organophosphorus-sensitive phenylvalerate- and acetylcholine-hydrolyzing activities in chicken brainCharacterization and Evolution of Exposure to Volatile Organic Compounds in the Spanish Shoemaking Industry over a 5-Year PeriodRecovery of neuropathy target esterase activity after inhibition with mipafox and O-hexyl O-2,5-dichlorophenyl phosphoramidate in bovine chromaffin cell culturesDichlorophenyl phosphoramidates as substrates for avian and mammalian liver phosphotriesterases: activity levels, calcium dependence and stereospecificityEnzyme concentration as an important factor in the in vitro testing of the stereospecificity of the enzymatic hydrolysis of organophosphorus compoundsChicken Serum Albumin Hydrolyzes Dichlorophenyl Phosphoramidates by a Mechanism Based on Transient PhosphorylationPhosphotriesterase activity identified in purified serum albuminsAn automatable microassay for phenyl valerate esterase activities sensitive to organophosphorus compoundsThe role of nicotinic receptors and calcium channels in mipafox induced inhibition of catecholamine release in bovine chromaffin cellsEffect of some metallic cations and organic compounds on theO-hexylO-2,5-dichlorophenyl phosphoramidate hydrolysing activity in hen plasma
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P50
description
onderzoeker
@nl
researcher, ORCID id # 0000-0002-1594-8940
@en
name
Miguel A Sogorb
@ast
Miguel A Sogorb
@en
Miguel A Sogorb
@es
Miguel A Sogorb
@nl
type
label
Miguel A Sogorb
@ast
Miguel A Sogorb
@en
Miguel A Sogorb
@es
Miguel A Sogorb
@nl
prefLabel
Miguel A Sogorb
@ast
Miguel A Sogorb
@en
Miguel A Sogorb
@es
Miguel A Sogorb
@nl
P106
P1153
6701750244
P21
P31
P496
0000-0002-1594-8940