mTORC1 Overactivation as a Key Aging Factor in the Progression to Type 2 Diabetes Mellitus

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mTORC1 Overactivation as a Key Aging Factor in the Progression to Type 2 Diabetes Mellitus

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наукова стаття, опублікована у 2018

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mTORC1 Overactivation as a Key ...... on to Type 2 Diabetes Mellitus

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mTORC1 Overactivation as a Key ...... on to Type 2 Diabetes Mellitus

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mTORC1 Overactivation as a Key ...... on to Type 2 Diabetes Mellitus

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mTORC1 Overactivation as a Key ...... on to Type 2 Diabetes Mellitus

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mTORC1 Overactivation as a Key ...... on to Type 2 Diabetes Mellitus

@en

mTORC1 Overactivation as a Key ...... on to Type 2 Diabetes Mellitus

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P1476

mTORC1 Overactivation as a Key ...... on to Type 2 Diabetes Mellitus

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Carlos Guillén

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Manuel Benito

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TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking

Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

Upregulation of the mammalian target of rapamycin complex 1 pathway by Ras homolog enriched in brain in pancreatic beta-cells leads to increased beta-cell mass and prevention of hyperglycemia

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

AMPK phosphorylation of raptor mediates a metabolic checkpoint

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621

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scholarly article

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10.3389/FENDO.2018.00621

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English

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2018-01-01T00:00:00Z

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30386301

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P921

type-2 diabetes

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6198057

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