p62-Keap1-NRF2-ARE Pathway: A Contentious Player for Selective Targeting of Autophagy, Oxidative Stress and Mitochondrial Dysfunction in Prion Diseases

about

p62-Keap1-NRF2-ARE Pathway: A Contentious Player for Selective Targeting of Autophagy, Oxidative Stress and Mitochondrial Dysfunction in Prion Diseases

Item

http://www.wikidata.org/entity/Q58583990

description

scientific article published on 04 October 2018

@en

wetenschappelijk artikel

@nl

наукова стаття, опублікована у 2018

@uk

name

p62-Keap1-NRF2-ARE Pathway: A ...... Dysfunction in Prion Diseases

@en

p62-Keap1-NRF2-ARE Pathway: A ...... Dysfunction in Prion Diseases

@nl

type

Item

label

p62-Keap1-NRF2-ARE Pathway: A ...... Dysfunction in Prion Diseases

@en

p62-Keap1-NRF2-ARE Pathway: A ...... Dysfunction in Prion Diseases

@nl

prefLabel

p62-Keap1-NRF2-ARE Pathway: A ...... Dysfunction in Prion Diseases

@en

p62-Keap1-NRF2-ARE Pathway: A ...... Dysfunction in Prion Diseases

@nl

P1476

p62-Keap1-NRF2-ARE Pathway: A ...... Dysfunction in Prion Diseases

@en

P2093

Deming Zhao

http://www.w3.org/2001/XMLSchema#string

Lifeng Yang

http://www.w3.org/2001/XMLSchema#string

Mazhar Hussain Mangi

http://www.w3.org/2001/XMLSchema#string

Naveed Sabir

http://www.w3.org/2001/XMLSchema#string

Tariq Hussain

http://www.w3.org/2001/XMLSchema#string

P2860

Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription

BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.

A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration

P304

310

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.3389/FNMOL.2018.00310

http://www.w3.org/2001/XMLSchema#string

P407

English

P478

http://www.w3.org/2001/XMLSchema#string

P50

Syed Zahid Ali Shah

P577

2018-10-04T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

30337853

http://www.w3.org/2001/XMLSchema#string

P921

molecular biology

P932

6180192

http://www.w3.org/2001/XMLSchema#string