about
RBR E3 ubiquitin ligases: new structures, new insights, new questionsStructure and dynamics of calmodulin (CaM) bound to nitric oxide synthase peptides: effects of a phosphomimetic CaM mutationStructure of the HHARI Catalytic Domain Shows Glimpses of a HECT E3 LigaseIntraprotein electron transfer in inducible nitric oxide synthase holoenzymePivotal role for the ubiquitin Y59-E51 loop in lysine 48 polyubiquitination.Suramin inhibits cullin-RING E3 ubiquitin ligases.A snapshot of ubiquitin chain elongation: lysine 48-tetra-ubiquitin slows down ubiquitination.Differential binding of calmodulin domains to constitutive and inducible nitric oxide synthase enzymes.Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.Dual-targeted labeling of proteins using cysteine and selenomethionine residues.Generation of phospho-ubiquitin variants by orthogonal translation reveals codon skipping.Calcium-deficient calmodulin binding and activation of neuronal and inducible nitric oxide synthases.Binding and activation of nitric oxide synthase isozymes by calmodulin EF hand pairs.Association of the disordered C-terminus of CDC34 with a catalytically bound ubiquitin.H, C, and N resonance assignments of the C-terminal lobe of the human HECT E3 ubiquitin ligase ITCHEnzyme Kinetics from Circular Dichroism of Insulin Reveals Mechanistic Insights into the Regulation of Insulin-degrading EnzymeResveratrol Sustains Insulin-Degrading Enzyme Activity toward Aβ42Selective labeling of selenomethionine residues in proteins with a fluorescent derivative of benzyl bromideFRET conformational analysis of calmodulin binding to nitric oxide synthase peptides and enzymesRegulation of mammalian nitric oxide synthases by electrostatic interactions in the linker region of calmodulinThe Longest Amyloid-β Precursor Protein Intracellular Domain Produced with Aβ42 Forms β-Sheet-Containing Monomers That Self-Assemble and Are Proteolyzed by Insulin-Degrading EnzymeA subset of calcium-binding S100 proteins show preferential heterodimerizationRapid and efficient purification of Drosophila homeodomain transcription factors for biophysical characterizationHECT E3 ubiquitin ligases - emerging insights into their biological roles and disease relevance
P50
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P50
description
researcher ORCID ID = 0000-0002-0699-155X
@en
wetenschapper
@nl
name
Donald E Spratt
@ast
Donald E Spratt
@en
Donald E Spratt
@es
Donald E Spratt
@nl
type
label
Donald E Spratt
@ast
Donald E Spratt
@en
Donald E Spratt
@es
Donald E Spratt
@nl
prefLabel
Donald E Spratt
@ast
Donald E Spratt
@en
Donald E Spratt
@es
Donald E Spratt
@nl
P106
P1153
8645038200
P31
P496
0000-0002-0699-155X