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Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar TyphimuriumSelectively reduced intracellular proliferation of Salmonella enterica serovar typhimurium within APCs limits antigen presentation and development of a rapid CD8 T cell response.Pathogen proliferation governs the magnitude but compromises the function of CD8 T cellsMutation in the Fas pathway impairs CD8+ T cell memory.Delayed expansion and contraction of CD8+ T cell response during infection with virulent Salmonella typhimurium.A reduced antigen load in vivo, rather than weak inflammation, causes a substantial delay in CD8+ T cell priming against Mycobacterium bovis (bacillus Calmette-Guérin).Immune dysregulation may contribute to disease pathogenesis in spinal muscular atrophy miceHolocranohistochemistry enables the visualization of α-synuclein expression in the murine olfactory system and discovery of its systemic anti-microbial effectsCaspase-3 is transiently activated without cell death during early antigen driven expansion of CD8(+) T cells in vivo.Salmonella enterica serovar Typhimurium-induced placental inflammation and not bacterial burden correlates with pathology and fatal maternal diseaseType-I interferon signaling through ISGF3 complex is required for sustained Rip3 activation and necroptosis in macrophages.Lack of functional selectin ligand interactions compromises long term tumor protection by CD8+ T cells.Phosphatidylserine receptor-mediated recognition of archaeosome adjuvant promotes endocytosis and MHC class I cross-presentation of the entrapped antigen by phagosome-to-cytosol transport and classical processing.A Highly Effective Component Vaccine against Nontyphoidal Salmonella enterica Infections.cIAP1 and cIAP2 limit macrophage necroptosis by inhibiting Rip1 and Rip3 activation.Interleukin (IL) 4, in the absence of antigen stimulation, induces an anergy-like state in differentiated CD8+ TC1 cells: loss of IL-2 synthesis and autonomous proliferation but retention of cytotoxicity and synthesis of other cytokines.Targeting macrophage necroptosis for therapeutic and diagnostic interventions in atherosclerosis.Archaeosomes varying in lipid composition differ in receptor-mediated endocytosis and differentially adjuvant immune responses to entrapped antigenIL-10 produced by trophoblast cells inhibits phagosome maturation leading to profound intracellular proliferation of Salmonella enterica Typhimurium.Inhibition of ROS and upregulation of inflammatory cytokines by FoxO3a promotes survival against Salmonella typhimuriumActivation of dendritic cells by liposomes prepared from phosphatidylinositol mannosides from Mycobacterium bovis bacillus Calmette-Guerin and adjuvant activity in vivo.Clinical Isolates of Pseudomonas aeruginosa from Chronically Infected Cystic Fibrosis Patients Fail To Activate the Inflammasome during Both Stable Infection and Pulmonary Exacerbation.VEGF-Mediated Induction of PRD1-BF1/Blimp1 Expression Sensitizes Tumor Vasculature to Oncolytic Virus Infection.Complexed soluble IL-7 receptor α and IL-7 increase IL-7-mediated proliferation and viability of CD8⁺ T-cells in vitro.Perioperative influenza vaccination reduces postoperative metastatic disease by reversing surgery-induced dysfunction in natural killer cells.Transcription factor Batf3 is important for development of CD8+ T-cell response against a phagosomal bacterium regardless of the location of antigen.Culling of APCs by inflammatory cell death pathways restricts TIM3 and PD-1 expression and promotes the survival of primed CD8 T cells.Pregnancy impairs the innate immune resistance to Salmonella typhimurium leading to rapid fatal infection.Increased CD8+ T cell memory to concurrent infection at the expense of increased erosion of pre-existing memory: the paradoxical role of IL-15.Archaeosomes induce long-term CD8+ cytotoxic T cell response to entrapped soluble protein by the exogenous cytosolic pathway, in the absence of CD4+ T cell help.The expanding universe of T-cell subsets: Th1, Th2 and more.Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines.Functions of CD8 T-cell subsets secreting different cytokine patterns.K45A mutation of RIPK1 results in poor necroptosis and cytokine signaling in macrophages, which impacts inflammatory responses in vivo.Brief Communication; A Heterologous Oncolytic Bacteria-Virus Prime-Boost Approach for Anticancer Vaccination in Mice.Intracellular bacterial vectors that induce CD8(+) T cells with similar cytolytic abilities but disparate memory phenotypes provide contrasting tumor protection.Prolonged antigen presentation, APC-, and CD8+ T cell turnover during mycobacterial infection: comparison with Listeria monocytogenes.Lack of functional selectin-ligand interactions enhances innate immune resistance to systemic Listeria monocytogenes infection.Modulation of antigenic location converts chronic into acute infection by forcing CD8+ T cell recognition.IFN-gamma expressed by T cells regulates the persistence of antigen presentation by limiting the survival of dendritic cells.
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description
researcher ORCID ID = 0000-0002-2462-7137
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wetenschapper
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Subash Sad
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Subash Sad
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Subash Sad
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P106
P1153
7004195667
P31
P496
0000-0002-2462-7137