about
SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7Stoichiometry of active smad-transcription factor complexes on DNAThe AMPA receptor GluR2 C terminus can mediate a reversible, ATP-dependent interaction with NSF and alpha- and beta-SNAPsNovel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABPBMP9 is a proliferative and survival factor for human hepatocellular carcinoma cellsDifferent Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif.A rapid and sensitive bioassay for the simultaneous measurement of multiple bone morphogenetic proteins. Identification and quantification of BMP4, BMP6 and BMP9 in bovine and human serum.Regulation of cell proliferation and apoptosis in neuroblastoma cells by ccp1, a FGF2 downstream gene.Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter.A complex secretory program orchestrated by the inflammasome controls paracrine senescence.Developments in Burkitt's lymphoma: novel cooperations in oncogenic MYC signaling.E3 ubiquitin ligase HOIP attenuates apoptotic cell death induced by cisplatin.Transforming growth factor-β directly induces p53-up-regulated modulator of apoptosis (PUMA) during the rapid induction of apoptosis in myc-driven B-cell lymphomas.Exosome-mediated transfer from the tumor microenvironment increases TGFβ signaling in squamous cell carcinomaNCAM is at the heart of reciprocal regulation of E-cadherin- and integrin-mediated adhesions via signaling modulation.TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling.Targeting the BCL-2 family in malignancies of germinal centre origin.Switching TGFβ from a tumor suppressor to a tumor promoter.A novel Xenopus Smad-interacting forkhead transcription factor (XFast-3) cooperates with XFast-1 in regulating gastrulation movements.The Promise of Genomics and the Development of Targeted Therapies for Cutaneous Squamous Cell Carcinoma.Methylated tissue factor pathway inhibitor 2 (TFPI2) DNA in serum is a biomarker of metastatic melanoma.Mutational activation of BRAF confers sensitivity to transforming growth factor beta inhibitors in human cancer cells.Phosphoinositide 3-kinase/AKT/mTORC1/2 signaling determines sensitivity of Burkitt's lymphoma cells to BH3 mimetics.TGF-beta induces apoptosis in human B cells by transcriptional regulation of BIK and BCL-XL.DNA damage in human B cells can induce apoptosis, proceeding from G1/S when p53 is transactivation competent and G2/M when it is transactivation defective.Apoptosis induced by TGF-beta 1 in Burkitt's lymphoma cells is caspase 8 dependent but is death receptor independent.Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinomaEpstein-Barr virus EBNA-LP and transcription regulation properties of pRB, p107 and p53 in transfection assays.Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development.Cell growth effects of Epstein-Barr virus leader protein.TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis.Crosstalk between p53 and TGF-β Signalling.Targeting BRAF-mutant tumours with TGFBR1 inhibitors.Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity.Loss of TGF-β signaling drives cSCC from skin stem cells - More evidence.TSC22 in mammary gland development and breast cancer.Fatal attractions? Correlations of CXCL12-CXCR4-CXCR7 expression with disease progression in melanoma and Kaposi sarcoma.Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma.Differing contributions of LIMK and ROCK to TGFβ-induced transcription, motility and invasionThe genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature
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description
researcher ORCID ID = 0000-0002-6264-4253
@en
wetenschapper
@nl
name
Gareth J Inman
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Gareth J Inman
@en
Gareth J Inman
@nl
type
label
Gareth J Inman
@ast
Gareth J Inman
@en
Gareth J Inman
@nl
prefLabel
Gareth J Inman
@ast
Gareth J Inman
@en
Gareth J Inman
@nl
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P21
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0000-0002-6264-4253