Altering Nitrogen Heterocycles of AZD2461 Affords High Affinity Poly(ADP-ribose) Polymerase-1 Inhibitors with Decreased P-Glycoprotein Interactions

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Altering Nitrogen Heterocycles of AZD2461 Affords High Affinity Poly(ADP-ribose) Polymerase-1 Inhibitors with Decreased P-Glycoprotein Interactions

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scientific article published on 28 August 2018

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wetenschappelijk artikel

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наукова стаття, опублікована в серпні 2018

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Altering Nitrogen Heterocycles of AZD2461 Affords High Affinity Poly

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Altering Nitrogen Heterocycles ...... ed P-Glycoprotein Interactions

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Altering Nitrogen Heterocycles of AZD2461 Affords High Affinity Poly

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Altering Nitrogen Heterocycles ...... ed P-Glycoprotein Interactions

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Altering Nitrogen Heterocycles of AZD2461 Affords High Affinity Poly

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Altering Nitrogen Heterocycles ...... ed P-Glycoprotein Interactions

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P1476

Altering Nitrogen Heterocycles ...... ed P-Glycoprotein Interactions

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P2093

Laura N Puentes

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Mehran Makvandi

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Robert H Mach

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Sean W Reilly

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P2860

High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

Successes and Challenges of PARP Inhibitors in Cancer Therapy

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers.

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

Essential role of poly(ADP-ribosyl)ation in cocaine action

4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1.

PARP1 enhances inflammatory cytokine expression by alteration of promoter chromatin structure in microglia.

Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors.

Non-invasive PET Imaging of PARP1 Expression in Glioblastoma Models.

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9997-10001

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scholarly article

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10.1021/ACSOMEGA.8B00896

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P407

English

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P478

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Chia-Ju Hsieh

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2018-08-28T00:00:00Z

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30198004

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6120739

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