Low Peripheral T Follicular Helper Cells in Perinatally HIV-Infected Children Correlate With Advancing HIV Disease

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Low Peripheral T Follicular Helper Cells in Perinatally HIV-Infected Children Correlate With Advancing HIV Disease

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наукова стаття, опублікована у 2018

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Low Peripheral T Follicular He ...... ate With Advancing HIV Disease

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Low Peripheral T Follicular He ...... ate With Advancing HIV Disease

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Low Peripheral T Follicular He ...... ate With Advancing HIV Disease

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Low Peripheral T Follicular He ...... ate With Advancing HIV Disease

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Low Peripheral T Follicular He ...... ate With Advancing HIV Disease

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Low Peripheral T Follicular He ...... ate With Advancing HIV Disease

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Low Peripheral T Follicular He ...... ate With Advancing HIV Disease

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Aabid Ahmed

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Adam Kravietz

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Alka Khaitan

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Bret McCarty

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Derya Unutmaz

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Fatma Marshed

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Mussa Mwamzuka

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Patricia Alvarez

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Tiina Ilmet

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William Borkowsky

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HIV-1 envelope protein binds to and signals through integrin α4β7, the gut mucosal homing receptor for peripheral T cells

Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150)

Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production

Follicular helper CD4 T cells (TFH)

Proportions of circulating follicular helper T cells are reduced and correlate with memory B cells in HIV-infected children.

PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells

Frequency and phenotype of B cell subpopulations in young and aged HIV-1 infected patients receiving ART.

Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction.

Early preservation of CXCR5+ PD-1+ helper T cells and B cell activation predict the breadth of neutralizing antibody responses in chronic HIV-1 infection.

Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion.

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1901

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scholarly article

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10.3389/FIMMU.2018.01901

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English

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Matthew Generoso

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2018-08-24T00:00:00Z

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30197641

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6117426

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