Precision DNA demethylation ameliorates disease in lupus-prone mice

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Precision DNA demethylation ameliorates disease in lupus-prone mice

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scientific article published on 23 August 2018

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wetenschappelijk artikel

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наукова стаття, опублікована в серпні 2018

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Precision DNA demethylation ameliorates disease in lupus-prone mice

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Precision DNA demethylation ameliorates disease in lupus-prone mice

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Precision DNA demethylation ameliorates disease in lupus-prone mice

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Precision DNA demethylation ameliorates disease in lupus-prone mice

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Precision DNA demethylation ameliorates disease in lupus-prone mice

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Precision DNA demethylation ameliorates disease in lupus-prone mice

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P1476

Precision DNA demethylation ameliorates disease in lupus-prone mice

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George C Tsokos

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Hao Li

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Maria G Tsokos

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Philip Kong

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Sean Bickerton

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Tarek M Fahmy

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Vaishali R Moulton

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Yi Li

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Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

CD3Z hypermethylation is associated with severe clinical manifestations in systemic lupus erythematosus and reduces CD3ζ-chain expression in T cells.

Human TCR-alpha beta+ CD4- CD8- T cells can derive from CD8+ T cells and display an inflammatory effector phenotype

Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

Treating activated CD4+ T cells with either of two distinct DNA methyltransferase inhibitors, 5-azacytidine or procainamide, is sufficient to cause a lupus-like disease in syngeneic mice.

Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces.

Epigenetics and T-cell immunity.

5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy.

Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys

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scholarly article

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10.1172/JCI.INSIGHT.120880

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English

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Amir Sharabi

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2018-08-23T00:00:00Z

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30135300

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6141184

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