Distinct multilevel misregulations of Parkin and PINK1 revealed in cell and animal models of TDP-43 proteinopathy

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Distinct multilevel misregulations of Parkin and PINK1 revealed in cell and animal models of TDP-43 proteinopathy

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im September 2018 veröffentlichter wissenschaftlicher Artikel

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scientific article published on 20 September 2018

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wetenschappelijk artikel

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наукова стаття, опублікована у вересні 2018

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Distinct multilevel misregulat ...... models of TDP-43 proteinopathy

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Distinct multilevel misregulat ...... models of TDP-43 proteinopathy

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Distinct multilevel misregulat ...... models of TDP-43 proteinopathy

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Distinct multilevel misregulat ...... models of TDP-43 proteinopathy

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Distinct multilevel misregulat ...... models of TDP-43 proteinopathy

@en

Distinct multilevel misregulat ...... models of TDP-43 proteinopathy

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Distinct multilevel misregulat ...... models of TDP-43 proteinopathy

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Ang Li

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Caixia Qin

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Gang Duan

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Jian-Chiuan Li

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Jiangxia Ni

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Ke Xiang

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Kuili Tian

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Xing Sun

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Xu Cao

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Xue Deng

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P2860

PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

Ubiquitin is phosphorylated by PINK1 to activate parkin

Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS

Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

PINK1 cleavage at position A103 by the mitochondrial protease PARL.

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis

Evolutionary conservation and expression of human RNA-binding proteins and their role in human genetic disease

Mitochondrial dysfunction in amyotrophic lateral sclerosis - a valid pharmacological target?

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953

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scholarly article

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10.1038/S41419-018-1022-Y

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English

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Yanshan Fang

Chun-Hong Chen

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2018-09-20T00:00:00Z

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30237395

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immunology

cancer research

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6148241

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