Isocitrate dehydrogenase 1 mutation sensitizes intrahepatic cholangiocarcinoma to the BET inhibitor JQ1

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Isocitrate dehydrogenase 1 mutation sensitizes intrahepatic cholangiocarcinoma to the BET inhibitor JQ1

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im November 2018 veröffentlichter wissenschaftlicher Artikel

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wetenschappelijk artikel

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наукова стаття, опублікована в листопаді 2018

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Isocitrate dehydrogenase 1 mut ...... inoma to the BET inhibitor JQ1

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Isocitrate dehydrogenase 1 mut ...... inoma to the BET inhibitor JQ1

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Isocitrate dehydrogenase 1 mut ...... inoma to the BET inhibitor JQ1

@en

Isocitrate dehydrogenase 1 mut ...... inoma to the BET inhibitor JQ1

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Isocitrate dehydrogenase 1 mut ...... inoma to the BET inhibitor JQ1

@en

Isocitrate dehydrogenase 1 mut ...... inoma to the BET inhibitor JQ1

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P1476

Isocitrate dehydrogenase 1 mut ...... inoma to the BET inhibitor JQ1

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Hideaki Ijichi

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Hirofumi Kogure

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Hiroyuki Kato

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Keisuke Tateishi

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Keisuke Yamamoto

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Naminatsu Takahara

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Saburo Matsubara

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Suguru Mizuno

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Yasuo Tanaka

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Yousuke Nakai

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P2860

Selective inhibition of BET bromodomains

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

Recurring mutations found by sequencing an acute myeloid leukemia genome

IDH1 and IDH2 mutations in gliomas

Cholangiocarcinoma

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation

An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.

Identification of targetable FGFR gene fusions in diverse cancers.

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3602-3610

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scholarly article

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10.1111/CAS.13784

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English

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109

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Kazuhiko Koike

Hiroaki Fujiwara

Takuma Nakatsuka

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2018-11-01T00:00:00Z

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30156013

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P921

cancer research

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6215870

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