Natural Genetic Variation in Yeast Reveals That NEDD4 Is a Conserved Modifier of Mutant Polyglutamine Aggregation

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Natural Genetic Variation in Yeast Reveals That NEDD4 Is a Conserved Modifier of Mutant Polyglutamine Aggregation

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http://www.wikidata.org/entity/Q58748882

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im November 2018 veröffentlichter wissenschaftlicher Artikel

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scientific article published on 06 November 2018

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wetenschappelijk artikel

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наукова стаття, опублікована в листопаді 2018

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Natural Genetic Variation in Y ...... tant Polyglutamine Aggregation

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Natural Genetic Variation in Y ...... tant Polyglutamine Aggregation

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Natural Genetic Variation in Y ...... tant Polyglutamine Aggregation

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Natural Genetic Variation in Y ...... tant Polyglutamine Aggregation

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Natural Genetic Variation in Y ...... tant Polyglutamine Aggregation

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Natural Genetic Variation in Y ...... tant Polyglutamine Aggregation

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Natural Genetic Variation in Y ...... tant Polyglutamine Aggregation

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Akos A Gerencser

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Brandon Tavshanjian

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Gordon J Lithgow

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Kyu Chul Chang

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Robert E Hughes

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Theodore W Peters

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P2860

Autophagic clearance of polyQ proteins mediated by ubiquitin-Atg8 adaptors of the conserved CUET protein family

A genetic screening strategy identifies novel regulators of the proteostasis network

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

Evidence for a direct role of the Doa4 deubiquitinating enzyme in protein sorting into the MVB pathway.

A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease.

Components of a ubiquitin ligase complex specify polyubiquitination and intracellular trafficking of the general amino acid permease.

An inhibitor of a deubiquitinating enzyme regulates ubiquitin homeostasis.

The Doa4 deubiquitinating enzyme is functionally linked to the vacuolar protein-sorting and endocytic pathways.

Rsp5/Nedd4 is the main ubiquitin ligase that targets cytosolic misfolded proteins following heat stress.

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3421-3431

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scholarly article

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10.1534/G3.118.200289

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English

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Kathleen J Dumas

Christopher Nelson

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2018-11-06T00:00:00Z

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30194090

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6222566

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