NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis

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NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis

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scientific article published on 03 August 2018

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wetenschappelijk artikel

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наукова стаття, опублікована в серпні 2018

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NLRP3 inflammasome inhibitor O ...... rine models of acute arthritis

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NLRP3 inflammasome inhibitor O ...... rine models of acute arthritis

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NLRP3 inflammasome inhibitor O ...... rine models of acute arthritis

@en

NLRP3 inflammasome inhibitor O ...... rine models of acute arthritis

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NLRP3 inflammasome inhibitor O ...... rine models of acute arthritis

@en

NLRP3 inflammasome inhibitor O ...... rine models of acute arthritis

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P1476

NLRP3 inflammasome inhibitor O ...... rine models of acute arthritis

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Carlo Marchetti

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Charles A Dinarello

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Dennis M de Graaf

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Isak W Tengesdal

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Marije I Koenders

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Nick Powers

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Tania Azam

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P2860

A pilot study of IL-1 inhibition by anakinra in acute gout

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

Gout-associated uric acid crystals activate the NALP3 inflammasome

c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis

Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

Gout.

Identification of urate crystals in gouty synovial fluid.

Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies.

JNK-1 deficiency limits macrophage-mediated antigen-induced arthritis.

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s13075-018-1664-2

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169

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scholarly article

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10.1186/S13075-018-1664-2

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English

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Benjamin Swartzwelter

Leo A B Joosten

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2018-08-03T00:00:00Z

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P6179

1105974505

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P698

30075804

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P921

inflammasome

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6091035

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