Prognostic significance of PIK3CA mutation in stage IIB to IVA cervical cancers treated by concurrent chemoradiotherapy with weekly cisplatin

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Prognostic significance of PIK3CA mutation in stage IIB to IVA cervical cancers treated by concurrent chemoradiotherapy with weekly cisplatin

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im August 2018 veröffentlichter wissenschaftlicher Artikel

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wetenschappelijk artikel

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наукова стаття, опублікована в серпні 2018

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Prognostic significance of PIK ...... otherapy with weekly cisplatin

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Prognostic significance of PIK ...... otherapy with weekly cisplatin

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Prognostic significance of PIK ...... otherapy with weekly cisplatin

@en

Prognostic significance of PIK ...... otherapy with weekly cisplatin

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Prognostic significance of PIK ...... otherapy with weekly cisplatin

@en

Prognostic significance of PIK ...... otherapy with weekly cisplatin

@nl

P1476

Prognostic significance of PIK ...... otherapy with weekly cisplatin

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Ayumi Shikama

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Azusa Akiyama

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Bouchra Lachkar

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Chenyang Xu

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Hiroyuki Ochi

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Hiroyuki Yoshikawa

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Manabu Sakurai

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Nobutaka Tasaka

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Sari Nakao

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Shuang Zhang

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P2860

Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit

Cisplatin: mode of cytotoxic action and molecular basis of resistance

Regulation of the p85/p110alpha phosphatidylinositol 3'-kinase. Distinct roles for the n-terminal and c-terminal SH2 domains.

Activation of the PI3-K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer.

Insights into the oncogenic effects of PIK3CA mutations from the structure of p110alpha/p85alpha.

Oncogenic mutations in cervical cancer: genomic differences between adenocarcinomas and squamous cell carcinomas of the cervix.

Phosphatidyl inositol-3 kinase (PIK3CA) E545K mutation confers cisplatin resistance and a migratory phenotype in cervical cancer cells.

Phosphatidylinositol 3-kinase inhibition by LY294002 radiosensitizes human cervical cancer cell lines.

PIK3CA overexpression is a possible prognostic factor for favorable survival in ovarian clear cell carcinoma.

Dual blocking of PI3K and mTOR signaling by NVP-BEZ235 inhibits proliferation in cervical carcinoma cells and enhances therapeutic response.

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e11392

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scholarly article

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10.1097/MD.0000000000011392

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English

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2018-08-01T00:00:00Z

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30075505

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6081058

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