Live tuberculosis vaccines based onphoPmutants: a step towards clinical trials
about
PhoP: a missing piece in the intricate puzzle of Mycobacterium tuberculosis virulence.The fbpA/sapM double knock out strain of Mycobacterium tuberculosis is highly attenuated and immunogenic in macrophagesM.tuberculosis mutants lacking oxygenated mycolates show increased immunogenicity and protective efficacy as compared to M. bovis BCG vaccine in an experimental mouse model.Antibody response against PhoP efficiently discriminates among healthy individuals, tuberculosis patients and their contacts.Protective immunity afforded by attenuated, PhoP-deficient Mycobacterium tuberculosis is associated with sustained generation of CD4+ T-cell memory.How could we have better vaccines against tuberculosis?
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Live tuberculosis vaccines based onphoPmutants: a step towards clinical trials
description
im Januar 2008 veröffentlichter wissenschaftlicher Artikel
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wetenschappelijk artikel
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наукова стаття, опублікована в січні 2008
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name
Live tuberculosis vaccines based onphoPmutants: a step towards clinical trials
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Live tuberculosis vaccines based onphoPmutants: a step towards clinical trials
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type
label
Live tuberculosis vaccines based onphoPmutants: a step towards clinical trials
@en
Live tuberculosis vaccines based onphoPmutants: a step towards clinical trials
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Live tuberculosis vaccines based onphoPmutants: a step towards clinical trials
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Live tuberculosis vaccines based onphoPmutants: a step towards clinical trials
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P2093
P2860
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P1476
Live tuberculosis vaccines based onphoPmutants: a step towards clinical trials
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P2093
Ainhoa Arbués
Brigitte Gicquel
Esther Pérez
Jesus A Gonzalo Asensio
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P304
P356
10.1517/14712598.8.2.201
P407
P577
2008-01-14T00:00:00Z