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Nucleoside modifications in the regulation of gene expression: focus on tRNAA distinctive RNA fold: the solution structure of an analogue of the yeast tRNAPhe T Psi C domainContribution of dihydrouridine in folding of the D-arm in tRNAS-Geranyl-2-thiouridine wobble nucleosides of bacterial tRNAs; chemical and enzymatic synthesis of S-geranylated-RNAs and their physicochemical characterizationSynthesis and properties of uniquely modified oligoribonucleotides: yeast tRNA(Phe) fragments with 6-methyluridine and 5,6-dimethyluridine at site-specific positions.A hydantoin isoform of cyclic N6-threonylcarbamoyladenosine (ct6A) is present in tRNAsIdentification of 2-methylthio cyclic N6-threonylcarbamoyladenosine (ms2ct6A) as a novel RNA modification at position 37 of tRNAsC5-substituents of uridines and 2-thiouridines present at the wobble position of tRNA determine the formation of their keto-enol or zwitterionic forms - a factor important for accuracy of reading of guanosine at the 3΄-end of the mRNA codons.2-Thiouracil deprived of thiocarbonyl function preferentially base pairs with guanine rather than adenine in RNA and DNA duplexesReaction of S-geranyl-2-thiouracil modified oligonucleotides with alkyl amines leads to the N2-alkyl isocytosine derivatives.Modified constructs of the tRNA TPsiC domain to probe substrate conformational requirements of m(1)A(58) and m(5)U(54) tRNA methyltransferasesEffect of base modifications on structure, thermodynamic stability, and gene silencing activity of short interfering RNA.Specific Silencing of L392V PSEN1 Mutant Allele by RNA Interference.Histamine modified 2'-deoxyriboadenosine--potential copper binding site in DNAzymes.Single atom modification (O-->S) of tRNA confers ribosome binding.Desulfuration of 2-thiouridine with hydrogen peroxide in the physiological pH range 6.6-7.6 is pH-dependent and results in two distinct products.Accurate translation of the genetic code depends on tRNA modified nucleosides.Site-selected introduction of modified purine and pyrimidine ribonucleosides into RNA by automated phosphoramidite chemistry.Transformation of a wobble 2-thiouridine to 2-selenouridine via S-geranyl-2-thiouridine as a possible cellular pathway.Preparation of short interfering RNA containing the modified nucleosides 2-thiouridine, pseudouridine, or dihydrouridine.Novel enamine derivatives of 5,6-dihydro-2'-deoxyuridine formed in reductive amination of 5-formyl-2'-deoxyuridine.Nucleosides. CXLVIII. Synthesis of 6-(beta-D-ribofuranosyl)picolinamide. A novel C-nucleoside from D-ribonolactone.The influence of the C5 substituent on the 2-thiouridine desulfuration pathway and the conformational analysis of the resulting 4-pyrimidinone products.DNA binding and cleavage studies of copper(II) complexes with 2'-deoxyadenosine modified histidine moiety.Acid-base and metal ion binding properties of 2-thiocytidine in aqueous solution.Cytochrome C catalyzes the hydrogen peroxide-assisted oxidative desulfuration of 2-thiouridines in transfer RNAs.Post-synthetic conversion of 5-pivaloyloxymethyluridine present in a support-bound RNA oligomer into biologically relevant derivatives of 5-methyluridine.Efficient synthesis of 2'-deoxyzebularine and its α-anomer by the silyl method of N-glycosylation. Crystal structures and conformational study in solution.An efficient approach for conversion of 5-substituted 2-thiouridines built in RNA oligomers into corresponding desulfured 4-pyrimidinone products.Efficient conversion of N6-threonylcarbamoyladenosine (t6A) into a tRNA native hydantoin cyclic form (ct6A) performed at nucleoside and oligoribonucleotide levels.Nano LC-MS using capillary columns enables accurate quantification of modified ribonucleosides at low femtomol levelsImpact of histidine residue on chelating ability of 2′-deoxyriboadenosinePresence and coding properties of 2'-O-methyl-5-carbamoylmethyluridine (ncm5Um) in the wobble position of the anticodon of tRNA(Leu) (U*AA) from brewer's yeastFormation of the [b+41]+. ion in the mass spectra of 2-thiouridinesDesulfurization of 2-thiouracil nucleosides: conformational studies of 4-pyrimidinone nucleosidesStability studies on the newly discovered cyclic form of tRNA N(6)-threonylcarbamoyladenosine (ct(6)A)Escherichia coli tRNA 2-selenouridine synthase (SelU) converts S2U-RNA to Se2U-RNA via S-geranylated-intermediateChemical Synthesis of Oligoribonucleotide (ASL of tRNALys T. brucei) Containing a Recently Discovered Cyclic Form of 2-Methylthio-N6 -threonylcarbamoyladenosine (ms2 ct6 A)C5-Substituted 2-Selenouridines Ensure Efficient Base Pairing with Guanosine; Consequences for Reading the NNG-3' Synonymous mRNA CodonsRole of modified nucleosides of yeast tRNA(Phe) in ribosomal binding
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researcher ORCID ID = 0000-0003-3240-1143
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wetenschapper
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E Sochacka
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P106
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6603960757
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