about
Mitochondria, calcium and cell death: a deadly triad in neurodegenerationBothrops snake myotoxins induce a large efflux of ATP and potassium with spreading of cell damage and painA Lys49-PLA2 myotoxin of Bothrops asper triggers a rapid death of macrophages that involves autocrine purinergic receptor signaling.The Concerted Action of Mitochondrial Dynamics and Positioning: New Characters in Cancer Onset and Progression.Mitofusin-2 knockdown increases ER-mitochondria contact and decreases amyloid β-peptide productionPresenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk.Mitochondria-endoplasmic reticulum choreography: structure and signaling dynamics.Lymphocyte lipid rafts: structure and function.Mitofusin 2 ablation increases endoplasmic reticulum-mitochondria coupling.Lipid rafts in lymphocyte activation.Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models.Characterization of the ER-Targeted Low Affinity Ca(2+) Probe D4ER.Ca(2+) signalling in the Golgi apparatus.The endoplasmic reticulum-mitochondria coupling in health and disease: Molecules, functions and significance.Heterogeneity of Ca2+ handling among and within Golgi compartments.Grp94 acts as a mediator of curcumin-induced antioxidant defence in myogenic cells.Ca2+ hot spots on the mitochondrial surface are generated by Ca2+ mobilization from stores, but not by activation of store-operated Ca2+ channels.The C-terminal region of a Lys49 myotoxin mediates Ca2+ influx in C2C12 myotubes.Calcium imaging of muscle cells treated with snake myotoxins reveals toxin synergism and presence of acceptors.High content analysis of gamma-secretase activity reveals variable dominance of presenilin mutations linked to familial Alzheimer's disease.Calcium dynamics in the peroxisomal lumen of living cells.Reduction of Ca2+ stores and capacitative Ca2+ entry is associated with the familial Alzheimer's disease presenilin-2 T122R mutation and anticipates the onset of dementia.The presenilin 2 M239I mutation associated with familial Alzheimer's disease reduces Ca2+ release from intracellular stores.Diacylglycerol activates the influx of extracellular cations in T-lymphocytes independently of intracellular calcium-store depletion and possibly involving endogenous TRP6 gene products.Dynamic properties of an inositol 1,4,5-trisphosphate- and thapsigargin-insensitive calcium pool in mammalian cell linesCharacterization of the cytotoxic effect of extracellular ATP in J774 mouse macrophages.Presenilin-2 dampens intracellular Ca2+ stores by increasing Ca2+ leakage and reducing Ca2+ uptakeOn the role of Mitofusin 2 in endoplasmic reticulum-mitochondria tetheringParadoxical Ca2+ rises induced by low external Ca2+ in rat hippocampal neurones.Physiological T cell activation starts and propagates in lipid rafts.Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases.Highlighting the Endoplasmic Reticulum-Mitochondria connection: focus on Mitofusin 2.SPLICS: a split green fluorescent protein-based contact site sensor for narrow and wide heterotypic organelle juxtaposition.Ca2+ dysregulation in neurons from transgenic mice expressing mutant presenilin 2.The Aging Mitochondria.TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to Mitochondria Ca2+ Transfer.Presenilin 2 Modulates Endoplasmic Reticulum-Mitochondria Coupling by Tuning the Antagonistic Effect of Mitofusin 2.Presenilin mutations linked to familial Alzheimer's disease reduce endoplasmic reticulum and Golgi apparatus calcium levels.Loss of cysteine 584 impairs the storage and release, but not the synthesis of von Willebrand factor.Mitofusin 2: from functions to disease.
P50
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P50
description
researcher ORCID ID = 0000-0001-6077-3265
@en
wetenschapper
@nl
name
Paola Pizzo
@ast
Paola Pizzo
@en
Paola Pizzo
@es
Paola Pizzo
@nl
type
label
Paola Pizzo
@ast
Paola Pizzo
@en
Paola Pizzo
@es
Paola Pizzo
@nl
altLabel
PAOLA PIZZO
@en
prefLabel
Paola Pizzo
@ast
Paola Pizzo
@en
Paola Pizzo
@es
Paola Pizzo
@nl
P1053
T-4874-2018
P106
P1153
35597536700
P21
P31
P496
0000-0001-6077-3265