about
Dual role of Sp3 transcription factor as an inducer of apoptosis and a marker of tumour aggressivenessSYK is a critical regulator of FLT3 in acute myeloid leukemiaAcadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell deathTumor suppressor function of miR-483-3p on squamous cell carcinomas due to its pro-apoptotic properties.SYK regulates mTOR signaling in AML.Metformin inhibits melanoma development through autophagy and apoptosis mechanisms.The anti-apoptotic Bcl-B protein inhibits BECN1-dependent autophagic cell death.Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced deathTargeting MYCN in neuroblastoma by BET bromodomain inhibitionBCL-B (BCL2L10) is overexpressed in patients suffering from multiple myeloma (MM) and drives an MM-like disease in transgenic miceTargeting autophagy to fight hematopoietic malignancies.Autophagy, a key mechanism of oncogenesis and resistance in leukemia.Ultrasound-assisted one-pot synthesis of anti-CML nucleosides featuring 1,2,3-triazole nucleobase under iron-copper catalysis.Imatinib triggers mesenchymal-like conversion of CML cells associated with increased aggressiveness.SPARC functions as an anti-stress factor by inactivating p53 through Akt-mediated MDM2 phosphorylation to promote melanoma cell survival.Persistent activation of the Fyn/ERK kinase signaling axis mediates imatinib resistance in chronic myelogenous leukemia cells through upregulation of intracellular SPARC.Inhibition of imatinib-mediated apoptosis by the caspase-cleaved form of the tyrosine kinase Lyn in chronic myelogenous leukemia cells.In vitro and in vivo anti-melanoma effects of ciglitazone.Apoptosis and erythroid differentiation triggered by Bcr-Abl inhibitors in CML cell lines are fully distinguishable processes that exhibit different sensitivity to caspase inhibition.A new posttranslational regulation of REDD1/DDIT4 through cleavage by caspase 3 modifies its cellular function.Targeting lysosomes to eradicate imatinib-resistant chronic myelogenous leukemia cells.Mechanism of action of the multikinase inhibitor Foretinib.Gene expression profiling of imatinib and PD166326-resistant CML cell lines identifies Fyn as a gene associated with resistance to BCR-ABL inhibitors.The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia.The p53/p21Cip1/ Waf1 pathway mediates the effects of SPARC on melanoma cell cycle progression.Structure elucidation of the new citharoxazole from the Mediterranean deep-sea sponge Latrunculia (Biannulata) citharistaeUsing antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer
P50
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P50
description
researcher ORCID ID = 0000-0002-3997-9282
@en
wetenschapper
@nl
name
Alexandre Puissant
@ast
Alexandre Puissant
@en
Alexandre Puissant
@es
Alexandre Puissant
@nl
type
label
Alexandre Puissant
@ast
Alexandre Puissant
@en
Alexandre Puissant
@es
Alexandre Puissant
@nl
prefLabel
Alexandre Puissant
@ast
Alexandre Puissant
@en
Alexandre Puissant
@es
Alexandre Puissant
@nl
P106
P31
P496
0000-0002-3997-9282