about
Effects of environmental pollutants on the reproduction and welfare of ruminantsMaternal protein-energy malnutrition during early pregnancy in sheep impacts the fetal ornithine cycle to reduce fetal kidney microvascular development.B-vitamin and homocysteine status determines ovarian response to gonadotropin treatment in sheepEffects of exposure to environmental chemicals during pregnancy on the development of the male and female reproductive axes.A methyl-deficient diet fed to rat dams during the peri-conception period programs glucose homeostasis in adult male but not female offspring.Large offspring syndrome and other consequences of ruminant embryo culture in vitro: relevance to blastocyst culture in human ART.In utero exposure to cigarette chemicals induces sex-specific disruption of one-carbon metabolism and DNA methylation in the human fetal liverDNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status.A methyl-deficient diet fed to rats during the pre- and peri-conception periods of development modifies the hepatic proteome in the adult offspring.Metabolomics: approaches to assessing oocyte and embryo quality.Healthy ageing of cloned sheep.Impact of endocrine-disrupting compounds (EDCs) on female reproductive health.Developmental programming of reproduction and fertility: what is the evidence?The periconceptional period, reproduction and long-term health of offspring: the importance of one-carbon metabolism.Parental diet, pregnancy outcomes and offspring health: metabolic determinants in developing oocytes and embryos.One-carbon metabolism and epigenetic regulation of embryo development.Epigenetics and developmental programming of welfare and production traits in farm animals.Impact of di-ethylhexylphthalate exposure on metabolic programming in P19 ECC-derived cardiomyocytes.Endogenous folates and single-carbon metabolism in the ovarian follicle, oocyte and pre-implantation embryo.Comment on "Effects of Arsenite during Fetal Development on Energy Metabolism and Susceptibility to Diet-Induced Fatty Liver Diseases in Male Mice" and "Mechanisms Underlying Latent Disease Risk Associated with Early-Life Arsenic Exposure: Current TDietary omega-3 and -6 polyunsaturated fatty acids affect the composition and development of sheep granulosa cells, oocytes and embryos.Epigenetic memory via concordant DNA methylation is inversely correlated to developmental potential of mammalian cells.Oocyte quality in lactating dairy cows fed on high levels of n-3 and n-6 fatty acids.Dietary carbohydrates and amino acids influence oocyte quality in dairy heifers.Nutrition, metabolism, and fertility in dairy cows: 3. Amino acids and ovarian function.Amino acid and fatty acid composition of follicular fluid as predictors of in-vitro embryo development.Human embryonic stem cell methyl cycle enzyme expression: modelling epigenetic programming in assisted reproduction?Radiographic assessment of the skeletons of Dolly and other clones finds no abnormal osteoarthritis.Temporary exposure of ovine embryos to an advanced uterine environment does not affect fetal weight but alters fetal muscle development.A mathematical model of the bovine oestrous cycle: simulating outcomes of dietary and pharmacological interventions.Feeding frequency has diet-dependent effects on plasma hormone concentrations but does not affect oocyte quality in dairy heifers fed fibre- or starch-based diets.Integration of physiological mechanisms that influence fertility in dairy cows.Physiological responses of cultured bovine granulosa cells to elevated temperatures under low and high oxygen in the presence of different concentrations of melatonin.Zygote donor nitrogen metabolism and in vitro embryo culture perturbs in utero development and IGF2R expression in ovine fetal tissues.Paternal low protein diet affects adult offspring cardiovascular and metabolic function in mice.Effects of omega-3 and -6 polyunsaturated fatty acids on ovine follicular cell steroidogenesis, embryo development and molecular markers of fatty acid metabolism.Fetal growth and development following temporary exposure of day 3 ovine embryos to an advanced uterine environment.Aberrant fetal growth and development after in vitro culture of sheep zygotes.Added dietary cobalt or vitamin B12, or injecting vitamin B12 does not improve performance or indicators of ketosis in pre- and post-partum Holstein-Friesian dairy cowsPaternal diet programs offspring health through sperm- and seminal plasma-specific pathways in mice
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P50
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onderzoeker
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researcher ORCID ID = 0000-0002-6375-215X
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Kevin D Sinclair
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Kevin D Sinclair
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Kevin D Sinclair
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Kevin D Sinclair
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Kevin D Sinclair
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Kevin D Sinclair
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7005880603
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0000-0002-6375-215X