about
STAT3β controls inflammatory responses and early tumor onset in skin and colon experimental cancer models.PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signallingNuclear Akt2 opposes limbal keratinocyte stem cell self-renewal by repressing a FOXO-mTORC1 signaling pathway.Rictor/mTORC2 deficiency enhances keratinocyte stress tolerance via mitohormesis.Constitutive STAT3 activation in epidermal keratinocytes enhances cell clonogenicity and favours spontaneous immortalization by opposing differentiation and senescence checkpoints.
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description
researcher ORCID ID = 0000-0002-3746-4605
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wetenschapper
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name
Beatrice Tassone
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Beatrice Tassone
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Beatrice Tassone
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Beatrice Tassone
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type
label
Beatrice Tassone
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Beatrice Tassone
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Beatrice Tassone
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Beatrice Tassone
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prefLabel
Beatrice Tassone
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Beatrice Tassone
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Beatrice Tassone
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Beatrice Tassone
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0000-0002-3746-4605