about
Whi2p links nutritional sensing to actin-dependent Ras-cAMP-PKA regulation and apoptosis in yeastActivation state of the Ras2 protein and glucose-induced signaling in Saccharomyces cerevisiae.Involvement of distinct G-proteins, Gpa2 and Ras, in glucose- and intracellular acidification-induced cAMP signalling in the yeast Saccharomyces cerevisiae.Live-cell imaging of endogenous Ras-GTP shows predominant Ras activation at the plasma membrane and in the nucleus in Saccharomyces cerevisiae.The role of feedback control mechanisms on the establishment of oscillatory regimes in the Ras/cAMP/PKA pathway in S. cerevisiaeDesign, synthesis, and biological evaluation of levoglucosenone-derived ras activation inhibitors.Characterization and properties of dominant-negative mutants of the ras-specific guanine nucleotide exchange factor CDC25(Mm).Structural features responsible for kinetic thermal stability of a carboxypeptidase from the archaebacterium Sulfolobus solfataricus.The transcription factor Swi4 is target for PKA regulation of cell size at the G1 to S transition in Saccharomyces cerevisiaeNuclear Ras2-GTP controls invasive growth in Saccharomyces cerevisiae.Evidence for adenylate cyclase as a scaffold protein for Ras2-Ira interaction in Saccharomyces cerevisie.A mutation in Saccharomyces cerevisiae adenylate cyclase, Cyr1K1876M, specifically affects glucose- and acidification-induced cAMP signalling and not the basal cAMP level.Structure-activity studies on arylamides and arysulfonamides Ras inhibitors.Lack of HXK2 induces localization of active Ras in mitochondria and triggers apoptosis in the yeast Saccharomyces cerevisiae.Role of guanine nucleotides in the regulation of the Ras/cAMP pathway in Saccharomyces cerevisiae.Involvement of Aif1 in apoptosis triggered by lack of Hxk2 in the yeast Saccharomyces cerevisiae.Methods to study the Ras2 protein activation state and the subcellular localization of Ras-GTP in Saccharomyces cerevisiae.Design and characterization of a new class of inhibitors of ras activation.Detection of cAMP and of PKA activity in Saccharomyces cerevisiae single cells using Fluorescence Resonance Energy Transfer (FRET) probes.The large N-terminal domain of Cdc25 protein of the yeast Saccharomyces cerevisiae is required for glucose-induced Ras2 activation.Nutrient-induced signal transduction through the protein kinase A pathway and its role in the control of metabolism, stress resistance, and growth in yeast.Glucose-Derived Ras Pathway Inhibitors: Evidence of Ras–Ligand Binding and Ras–GEF (Cdc25) Interaction Inhibition
P50
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P50
description
onderzoeker
@nl
researcher ORCID ID = 0000-0001-5104-508X
@en
name
Sonia Colombo
@ast
Sonia Colombo
@en
Sonia Colombo
@es
Sonia Colombo
@nl
type
label
Sonia Colombo
@ast
Sonia Colombo
@en
Sonia Colombo
@es
Sonia Colombo
@nl
prefLabel
Sonia Colombo
@ast
Sonia Colombo
@en
Sonia Colombo
@es
Sonia Colombo
@nl
P106
P1153
7006495355
P31
P496
0000-0001-5104-508X