Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state
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Simulation of alcohol action upon a detailed Purkinje neuron model and a simpler surrogate model that runs >400 times fasterATP1A2 Mutations in Migraine: Seeing through the Facets of an Ion Pump onto the Neurobiology of DiseaseFXYD5: Na(+)/K(+)-ATPase Regulator in Health and DiseaseCardiotonic Steroids as Modulators of NeuroinflammationCellular function and pathological role of ATP13A2 and related P-type transport ATPases in Parkinson's disease and other neurological disordersATP1A3 Mutation in Adult Rapid-Onset AtaxiaSequential substitution of K(+) bound to Na(+),K(+)-ATPase visualized by X-ray crystallography.Epithelial sodium transport and its control by aldosterone: the story of our internal environment revisitedNa+/Ca2+ exchange and Na+/K+-ATPase in the heartInhibition of K+ transport through Na+, K+-ATPase by capsazepine: role of membrane span 10 of the α-subunit in the modulation of ion gatingSystematic comparison of molecular conformations of H+,K+-ATPase reveals an important contribution of the A-M2 linker for the luminal gating.Hypothermia-induced dystonia and abnormal cerebellar activity in a mouse model with a single disease-mutation in the sodium-potassium pump.The Structure and Function of the Na,K-ATPase Isoforms in Health and Disease.Spherical Oligo-Silicic Acid SOSA Disclosed as Possible Endogenous Digitalis-Like Factor.Modulation by K+ Plus NH4+ of microsomal (Na+, K+)-ATPase activity in selected ontogenetic stages of the diadromous river shrimp Macrobrachium amazonicum (Decapoda, Palaemonidae).Microsecond molecular dynamics simulations of Mg²⁺- and K⁺-bound E1 intermediate states of the calcium pumpOrigins and functional diversification of salinity-responsive Na(+) , K(+) ATPase α1 paralogs in salmonids.Mechanism of potassium ion uptake by the Na(+)/K(+)-ATPase.Tuning of the Na,K-ATPase by the beta subunit.The selectivity of the Na(+)/K(+)-pump is controlled by binding site protonation and self-correcting occlusion.Profound regulation of Na/K pump activity by transient elevations of cytoplasmic calcium in murine cardiac myocytes.Glutamate Water Gates in the Ion Binding Pocket of Na+ Bound Na+, K+-ATPase.Arginine substitution of a cysteine in transmembrane helix M8 converts Na+,K+-ATPase to an electroneutral pump similar to H+,K+-ATPaseRoute, mechanism, and implications of proton import during Na+/K+ exchange by native Na+/K+-ATPase pumps.Fishing for holes in transporters: how protons breach the Na/K pump security gatesTargeting Na⁺/K⁺ -translocating adenosine triphosphatase in cancer treatment.Basal Glutathionylation of Na,K-ATPase α-Subunit Depends on Redox Status of Cells during the Enzyme BiosynthesisComputer modelling reveals new conformers of the ATP binding loop of Na+/K+-ATPase involved in the transphosphorylation process of the sodium pump.Specific phospholipid binding to Na,K-ATPase at two distinct sites.Of channels and pumps: different ways to boost the aldosterone?Rescue of Na+ affinity in aspartate 928 mutants of Na+,K+-ATPase by secondary mutation of glutamate 314.Critical role of γ-phosphate in structural transition of Na,K-ATPase upon ATP binding.Binding of ouabain and marinobufagenin leads to different structural changes in Na,K-ATPase and depends on the enzyme conformation.Importance of a Potential Protein Kinase A Phosphorylation Site of Na+,K+-ATPase and Its Interaction Network for Na+ BindingK+ congeners that do not compromise Na+ activation of the Na+,K+-ATPase: hydration of the ion binding cavity likely controls ion selectivity.Molecular Mechanisms and Kinetic Effects of FXYD1 and Phosphomimetic Mutants on Purified Human Na,K-ATPaseRelationship between intracellular Na+ concentration and reduced Na+ affinity in Na+,K+-ATPase mutants causing neurological disease.Second transmembrane helix (M2) and long range coupling in Ca²⁺-ATPase.Selective Assembly of Na,K-ATPase α2β2 Heterodimers in the Heart: DISTINCT FUNCTIONAL PROPERTIES AND ISOFORM-SELECTIVE INHIBITORS.Stimulation, inhibition, or stabilization of Na,K-ATPase caused by specific lipid interactions at distinct sites.
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Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state
description
article publié dans la revue scientifique Nature
@fr
scientific article published in Nature
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в Nature в жовтні 2013
@uk
name
Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state
@en
Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state
@nl
type
label
Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state
@en
Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state
@nl
prefLabel
Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state
@en
Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state
@nl
P2093
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Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state
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P2093
Chikashi Toyoshima
Haruo Ogawa
Ryuta Kanai
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P2888
P304
P356
10.1038/NATURE12578
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P577
2013-10-02T00:00:00Z
P6179
1023657224