The major substrates for TAP in vivo are derived from newly synthesized proteins
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Identification of sequences in the human peptide transporter subunit TAP1 required for transporter associated with antigen processing (TAP) functionViral inhibition of the transporter associated with antigen processing (TAP): a striking example of functional convergent evolutionVaricelloviruses avoid T cell recognition by UL49.5-mediated inactivation of the transporter associated with antigen processingThe transporter associated with antigen processing: function and implications in human diseasesBAG-6 is essential for selective elimination of defective proteasomal substratesWhole-genome survey of the putative ATP-binding cassette transporter family genes in Vitis viniferaLinkage of bacterial protein synthesis and presentation of MHC class I-restricted Listeria monocytogenes-derived antigenic peptidesA naturally processed rat major histocompatibility complex class I-associated viral peptide as target structure of borna disease virus-specific CD8+ T cells.Mapping and expression pattern analysis of key components of the major histocompatibility complex class I antigen processing and presentation pathway in a representative human renal cell carcinoma cell line.Varicellovirus UL 49.5 proteins differentially affect the function of the transporter associated with antigen processing, TAP.A distinct translation initiation mechanism generates cryptic peptides for immune surveillanceT cell detection of a B-cell tropic virus infection: newly-synthesised versus mature viral proteins as antigen sources for CD4 and CD8 epitope display.Folding of matrix metalloproteinase-2 prevents endogenous generation of MHC class-I restricted epitopeEpstein Barr virus-encoded EBNA1 interference with MHC class I antigen presentation reveals a close correlation between mRNA translation initiation and antigen presentation.Conformation of peptides bound to the transporter associated with antigen processing (TAP)Compartmentalized MHC class I antigen processing enhances immunosurveillance by circumventing the law of mass action.PA28αβ: the enigmatic magic ring of the proteasome?Visualizing high error levels during gene expression in living bacterial cells.Transient aggregation of ubiquitinated proteins during dendritic cell maturation.Glycoprotein folding in the endoplasmic reticulum.Perpetuation of immunological memory: a relay hypothesis.The MHC class I antigen presentation pathway: strategies for viral immune evasion.Selective cytotoxic T-lymphocyte targeting of tumor immune escape variants.Premature translational termination products are rapidly degraded substrates for MHC class I presentationSelf peptides and the peptidic self.Kinetics of antigen expression and epitope presentation during virus infection.Reduction in ATP levels triggers immunoproteasome activation by the 11S (PA28) regulator during early antiviral response mediated by IFNβ in mouse pancreatic β-cells.Non-conventional sources of peptides presented by MHC class I.Multicolour fluorescence-detection size-exclusion chromatography for structural genomics of membrane multiprotein complexesMajor histocompatibility complex class I-restricted antigen processing and presentation.Towards patient-specific tumor antigen selection for vaccination.Hydrophobicity as a driver of MHC class I antigen processing.Allosteric crosstalk between peptide-binding, transport, and ATP hydrolysis of the ABC transporter TAPMechanisms of MHC class I-restricted antigen presentation.Trypanosoma cruzi infection down-modulates the immunoproteasome biosynthesis and the MHC class I cell surface expression in HeLa cells.Tumor antigens and proteomics from the point of view of the major histocompatibility complex peptides.Ubiquitous Autofragmentation of Fluorescent Proteins Creates Abundant Defective Ribosomal Products (DRiPs) for Immunosurveillance.Generation of major histocompatibility complex class I antigens: functional interplay between proteasomes and TPPII.The processing of antigens delivered as DNA vaccines.The ABCs of immunology: structure and function of TAP, the transporter associated with antigen processing.
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The major substrates for TAP in vivo are derived from newly synthesized proteins
description
article publié dans la revue scientifique Nature
@fr
scientific article published in Nature
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wetenschappelijk artikel
@nl
наукова стаття, опублікована в Nature у квітні 2000
@uk
name
The major substrates for TAP in vivo are derived from newly synthesized proteins
@en
The major substrates for TAP in vivo are derived from newly synthesized proteins
@nl
type
label
The major substrates for TAP in vivo are derived from newly synthesized proteins
@en
The major substrates for TAP in vivo are derived from newly synthesized proteins
@nl
prefLabel
The major substrates for TAP in vivo are derived from newly synthesized proteins
@en
The major substrates for TAP in vivo are derived from newly synthesized proteins
@nl
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The major substrates for TAP in vivo are derived from newly synthesized proteins
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10.1038/35008103
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2000-04-01T00:00:00Z
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1052444880