Forming all-carbon quaternary stereogenic centres in acyclic systems from alkynes
about
Copper mediated carbometalation reactionsGeneration of stereochemically defined tetrasubstituted enolborinates by 1,4-hydroboration of α,β-unsaturated morpholine carboxamides with (diisopinocampheyl)borane.Oxenoids in organic synthesis.Turning unreactive copper acetylides into remarkably powerful and mild alkyne transfer reagents by oxidative umpolung.Electrophilic amination: the case of nitrenoids.Enantioselective allylic alkylation of stereodefined polysubstituted copper enolates as an entry to acyclic quaternary carbon stereocentres.Acyclic quaternary centers from asymmetric conjugate addition of alkylzirconium reagents to linear trisubstituted enones.Zirconocene catalyzed diastereoselective carbometalation of cyclobutenes.Stereocontrol of all-carbon quaternary centers through enantioselective desymmetrization of meso primary diols by organocatalyzed acyl transfer.Merging allylic carbon-hydrogen and selective carbon-carbon bond activation.Stereodefined acyclic trisubstituted metal enolates towards the asymmetric formation of quaternary carbon stereocentres.Modulable and highly diastereoselective carbometalations of cyclopropenes.Remote functionalization of hydrocarbons with reversibility enhanced stereocontrol.Ynamide Preactivation Allows a Regio- and Stereoselective Synthesis of α,β-Disubstituted Enamides.Ethanol as a Hydrogenating Agent: Palladium-Catalyzed Stereoselective Hydrogenation of Ynamides To Give Enamides.Asymmetric Catalytic Preparation of Polysubstituted Cyclopropanol and Cyclopropylamine Derivatives.(IPr)CuF-catalyzed α-site regiocontrolled trans-hydrofluorination of ynamides.Brook Rearrangement as a Trigger for the Ring Opening of Strained Carbocycles.Isoxazole-embedded allylic zinc reagent for the diastereoselective preparation of highly functionalized aldol-type derivatives bearing a stereocontrolled quaternary center.Organocatalytic enantioselective allylic alkylation of MBH carbonates with β-keto esters.Taming the carboxyl group for directed carbometalation: observations on the use of anions, dianions and ester enolates.One-pot zinc-promoted asymmetric alkynylation/brook-type rearrangement/ene-allene cyclization: highly selective formation of three new bonds and two stereocenters in acyclic systems.
P2860
Q28072759-A26A73BD-190D-406F-B894-D3459B87F9FEQ37542796-12544D18-8F70-49F4-94BA-B9D098875DD5Q38183253-43DAA1B7-7A09-4EAF-A9A7-DF1D4EA9B703Q38218769-7854E94C-1796-49B9-9C66-53F9FF1688FDQ38340331-0F3D45A3-D72A-460F-B0CE-D81F6F8D379AQ41833646-3A3B2CC9-750D-4682-89CF-5807333D28E0Q42029518-E19BB180-A07B-492D-BF95-E6143317F94AQ42314399-D5DC41BF-4E03-4BFF-BCFA-E03C92A8FF48Q44244060-3F995F40-9C5B-4863-88BA-AC90BB90A7BDQ46136230-49E88E74-21BF-4C18-B8DB-720FAE2CD8EAQ46862564-0916246D-1663-4E9E-AC83-6904A69767E9Q46959367-12628217-A97A-4AD1-BE7F-15673ABCE8D5Q47100392-7BD2EB00-A7CA-46DD-93DE-1F292C77BE12Q48185677-8AA0DBFE-5A4C-4838-BAA9-E9FF24B9274DQ48192750-935338C6-E06F-428B-A2F8-B835A8F478FCQ48269544-85F57CCE-EB1C-46CA-889C-7C86EA8B2BE7Q51228619-8167287F-2D58-498F-82C0-B04315BD5CF0Q52895598-D54E72BC-147B-45D0-A18F-896076387EC2Q53021603-50BFA33C-4C03-4D2D-95D0-EE26B19EF444Q54327923-60538318-D7FF-4574-A2A5-8BADF33DB0DFQ54687928-3745D287-57A2-46C6-84DF-F1877635F328Q54704314-445133F8-9383-40D7-AC5E-DC9D3ACAF6BB
P2860
Forming all-carbon quaternary stereogenic centres in acyclic systems from alkynes
description
article publié dans la revue scientifique Nature
@fr
scientific article published in Nature
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в Nature в жовтні 2012
@uk
name
Forming all-carbon quaternary stereogenic centres in acyclic systems from alkynes
@en
Forming all-carbon quaternary stereogenic centres in acyclic systems from alkynes
@nl
type
label
Forming all-carbon quaternary stereogenic centres in acyclic systems from alkynes
@en
Forming all-carbon quaternary stereogenic centres in acyclic systems from alkynes
@nl
prefLabel
Forming all-carbon quaternary stereogenic centres in acyclic systems from alkynes
@en
Forming all-carbon quaternary stereogenic centres in acyclic systems from alkynes
@nl
P2860
P50
P356
P1433
P1476
Forming all-carbon quaternary stereogenic centres in acyclic systems from alkynes
@en
P2093
Ilan Marek
Mark Botoshansky
P2860
P2888
P304
P356
10.1038/NATURE11569
P407
P577
2012-10-01T00:00:00Z
P6179
1004007831