Role of self-peptides in positively selecting the T-cell repertoire
about
Crossreactivity of a human autoimmune TCR is dominated by a single TCR loopαβ T cell receptors as predictors of health and diseaseT cells and their eons-old obsession with MHCDirect presentation is sufficient for an efficient anti-viral CD8+ T cell response.Antigen capture and archiving by lymphatic endothelial cells following vaccination or viral infectionParadoxical intrathymic positive selection in mice with only a covalently presented agonist peptideNegative selection of thymocytes expressing the D10 TCRThe dominant role of CD8+ dendritic cells in cross-presentation is not dictated by antigen capture.Models of self-peptide sampling by developing T cells identify candidate mechanisms of thymic selection.Altered positive selection due to corecognition of floppy peptide/MHC II conformers supports an integrative model of thymic selection.T cell mapping of one epitope from thyroglobulin inducing experimental autoimmune thyroiditis (EAT).The thymic education of developing T cells in self neuroendocrine principles.Diversity of T cell repertoire shaped by a single peptide ligand is critically affected by its amino acid residue at a T cell receptor contact.Autocrine IL-2 is required for secondary population expansion of CD8(+) memory T cells.A naturally processed mitochondrial self-peptide in complex with thymic MHC molecules functions as a selecting ligand for a viral-specific T cell receptor.CD4+ T cell division in irradiated mice requires peptides distinct from those responsible for thymic selectionInduction of a CD8+ cytotoxic T lymphocyte response by cross-priming requires cognate CD4+ T cell help.A mechanism for the major histocompatibility complex-linked resistance to autoimmunityStructural basis for the restoration of TCR recognition of an MHC allelic variant by peptide secondary anchor substitution.Quantitative analysis of the T cell repertoire selected by a single peptide-major histocompatibility complex.The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation.Conformational constraints involved in MHC class I restricted antigen presentation.Advances in direct T-cell alloreactivity: function, avidity, biophysics and structure.Endogenous-peptide-dependent alloreactivity: new scientific insights and clinical implications.T cells recognizing a 11mer influenza peptide complexed to H-2D(b) show promiscuity for peptide length.CD8+ T cell tolerance and autoimmunity to extra-thymic antigens.Processing of self-proteins and its impact on shaping the T cell repertoire, autoimmunity and immune regulation.Direct, help-independent priming of CD8+ T cells by adeno-associated virus-transduced hepatocytes.The somatically generated portion of T cell receptor CDR3α contributes to the MHC allele specificity of the T cell receptor.
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P2860
Role of self-peptides in positively selecting the T-cell repertoire
description
article publié dans la revue scientifique Nature
@fr
scientific article published in Nature
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в Nature в березні 1990
@uk
name
Role of self-peptides in positively selecting the T-cell repertoire
@en
Role of self-peptides in positively selecting the T-cell repertoire
@nl
type
label
Role of self-peptides in positively selecting the T-cell repertoire
@en
Role of self-peptides in positively selecting the T-cell repertoire
@nl
prefLabel
Role of self-peptides in positively selecting the T-cell repertoire
@en
Role of self-peptides in positively selecting the T-cell repertoire
@nl
P356
P1433
P1476
Role of self-peptides in positively selecting the T-cell repertoire
@en
P2093
Nikolić-Zugić J
P2888
P356
10.1038/344065A0
P407
P577
1990-03-01T00:00:00Z
P6179
1056438875