Phosphorylation-dependent binding of mitotic cyclins to Cdc6 contributes to DNA replication control
about
Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separasePrevention of DNA re-replication in eukaryotic cellsPreventing re-replication of chromosomal DNA.Re-replication of a centromere induces chromosomal instability and aneuploidyCks confers specificity to phosphorylation-dependent CDK signaling pathwaysThe Rix1 (Ipi1p-2p-3p) complex is a critical determinant of DNA replication licensing independent of their roles in ribosome biogenesis.Cdk1 coordinates cell-surface growth with the cell cycle.The septins function in G1 pathways that influence the pattern of cell growth in budding yeast.Regulation of Plasmodium falciparum Origin Recognition Complex subunit 1 (PfORC1) function through phosphorylation mediated by CDK-like kinase PK5Origin recognition and the chromosome cycleGEMC1 is a TopBP1-interacting protein required for chromosomal DNA replicationThe plant cell cycle: Pre-Replication complex formation and controlsMultiple regulatory mechanisms to inhibit untimely initiation of DNA replication are important for stable genome maintenance.Cdc6 ATPase activity regulates ORC x Cdc6 stability and the selection of specific DNA sequences as origins of DNA replication.Regulation of the final stage of mitosis by components of the pre-replicative complex and a polo kinase.Regulatory mechanisms that prevent re-initiation of DNA replication can be locally modulated at origins by nearby sequence elements.Cdc6 degradation requires phosphodegron created by GSK-3 and Cdk1 for SCFCdc4 recognition in Saccharomyces cerevisiae.Regulatory evolution in proteins by turnover and lineage-specific changes of cyclin-dependent kinase consensus sitesBehavior of replication origins in Eukaryota - spatio-temporal dynamics of licensing and firingSequential steps in DNA replication are inhibited to ensure reduction of ploidy in meiosis.DNA replication licensing control and rereplication prevention.Quality control in the initiation of eukaryotic DNA replication.Evolutionary conservation of the CDK targets in eukaryotic DNA replication initiation.Cryo-EM of dynamic protein complexes in eukaryotic DNA replication.Mechanisms and regulation of DNA replication initiation in eukaryotes.Emerging Roles for Ciz1 in Cell Cycle Regulation and as a Driver of Tumorigenesis.Role of Cdc6 During Oogenesis and Early Embryo Development in Mouse and Xenopus laevis.Cyclin-dependent kinase 4/6 activity is a critical determinant of pre-replication complex assembly.Warming up at the poles.Linkage between phosphorylation of the origin recognition complex and its ATP binding activity in Saccharomyces cerevisiae.Phosphorylation-dependent binding of cyclin B1 to a Cdc6-like domain of human separase.Control of Cdc6 accumulation by Cdk1 and MAPK is essential for completion of oocyte meiotic divisions in Xenopus.
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Phosphorylation-dependent binding of mitotic cyclins to Cdc6 contributes to DNA replication control
description
article publié dans la revue scientifique Nature
@fr
scientific article published in Nature
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wetenschappelijk artikel
@nl
наукова стаття, опублікована в Nature в жовтні 2004
@uk
name
Phosphorylation-dependent bind ...... tes to DNA replication control
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Phosphorylation-dependent bind ...... tes to DNA replication control
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type
label
Phosphorylation-dependent bind ...... tes to DNA replication control
@en
Phosphorylation-dependent bind ...... tes to DNA replication control
@nl
prefLabel
Phosphorylation-dependent bind ...... tes to DNA replication control
@en
Phosphorylation-dependent bind ...... tes to DNA replication control
@nl
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P356
P1433
P1476
Phosphorylation-dependent bind ...... tes to DNA replication control
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P2093
Satoru Mimura
Takashi Seki
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P2888
P304
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10.1038/NATURE03024
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P577
2004-10-20T00:00:00Z
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1006246362