about
Structural insights into the broad substrate specificity of carboxypeptidase T from Thermoactinomyces vulgarisZebra: a web server for bioinformatic analysis of diverse protein families.Computational design of a pH stable enzyme: understanding molecular mechanism of penicillin acylase's adaptation to alkaline conditionsPenicillin acylase-catalyzed ampicillin synthesis using a pH gradient: a new approach to optimization.pocketZebra: a web-server for automated selection and classification of subfamily-specific binding sites by bioinformatic analysis of diverse protein families.Bioinformatic analysis of protein families for identification of variable amino acid residues responsible for functional diversity.Highly efficient synthesis of ampicillin in an "aqueous solution-precipitate" system: repetitive addition of substrates in a semicontinuous process.Quantitative characterization of the nucleophile reactivity in penicillin acylase-catalyzed acyl transfer reactions.Study of nucleophile binding in the penicillin acylase active center. Kinetic analysis.Thermodynamic and kinetic stability of penicillin acylase from Escherichia coli.Efficient enantiomeric analysis of primary amines and amino alcohols by high-performance liquid chromatography with precolumn derivatization using novel chiral SH-reagent N-(R)-mandelyl-(S)-cysteine.Chiral high-performance liquid chromatography analysis of alpha-amino acid mixtures using a novel SH reagent--N-R-mandelyl-L-cysteine and traditional enantiomeric thiols for precolumn derivatization.Mustguseal: a Server for Multiple Structure-Guided Sequence Alignment of Protein Families.Crystal structures of carboxypeptidase T complexes with transition-state analogs.The visualCMAT: A web-server to select and interpret correlated mutations/co-evolving residues in protein families.Structure of the carboxypeptidase B complex with N-sulfamoyl-L-phenylalanine - a transition state analog of non-specific substrate.Tyrosyl-DNA Phosphodiesterase 1 Inhibitors: Usnic Acid Enamines Enhance the Cytotoxic Effect of Camptothecin.Kinetics of ampicillin synthesis catalyzed by penicillin acylase from E. coli in homogeneous and heterogeneous systems. Quantitative characterization of nucleophile reactivity and mathematical modeling of the process.2,5-Diketopiperazines: A New Class of Poly(ADP-ribose)polymerase Inhibitors.Active site titration as a tool for the evaluation of immobilization procedures of penicillin acylase.Bioinformatic analysis of the fold type I PLP-dependent enzymes reveals determinants of reaction specificity in l-threonine aldolase from Aeromonas jandaei.Molecular modeling of formate dehydrogenase: the formation of the Michaelis complexInvestigation of formate transport through the substrate channel of formate dehydrogenase by steered molecular dynamics simulationsSubstrate specificity of penicillin amidase from E. coliHydrophobicity of beta-lactam antibiotics. Explanation and prediction of their behaviour in various partitioning solvent systems and reversed-phase chromatographyAcyl group transfer by proteases forming an acylenzyme intermediate: kinetic model analysis (including hydrolysis of acylenzyme- nucleophile complex)The mechanism of the alpha-chymotrypsin and trypsin-catalyzed hydrolysis of amides. Evidence for the participation of the active serine in the amidase activity of trypsinPreparation and properties of penicillin amidase immobilized in polyelectrolyte complexesInfluence of the immunization against heterologous alcohol dehydrogenase on liver alcohol dehydrogenase isozymes and alcohol abuse of ratsThe interaction of amino acids with ophthaldialdehyde: a kinetic study and spectrophotometric assay of the reaction productContinuous spectrophotometric assay of human lysosomal cathepsin A/protective protein in normal and galactosialidosis cellsComparative modeling of substrate binding in the S1' subsite of serine carboxypeptidases from yeast, wheat, and humanEnantioselective penicillin acylase-catalyzed reactions. Factors governing substrate and stereospecificity of the enzymeKinetic study of penicillin acylase from Alcaligenes faecalisTotally enzymatic synthesis of peptides. Penicillin acylase-catalyzed protection and deprotection of amino groups as important building blocks of this strategyQuantum chemical studies of the catalytic mechanism of N-terminal nucleophile hydrolaseSoluble-insoluble immobilized enzymesAcyl group transfer by proteases forming acyl-enzyme intermediate: kinetic model analysisA new method for spectrophotometric assay of activity of cross-linked penicillin acylase aggregatesGuidelines for reporting of biocatalytic reactions
P50
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P50
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researcher ORCID ID = 0000-0002-1664-0307
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Vytas K Svedas
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Vytas K Svedas
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Vytas Švedas
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Vytas Švedas
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Витас Каятоно Швядас
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P106
P1153
7004619816
P21
P31
P496
0000-0002-1664-0307