Metabolism of fibrates by cytochrome P450s and UDP-glycosyltransferases in rat and human liver microsomes

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Peroxisome Proliferator-Activated Receptor α Activation Suppresses Cytochrome P450 Induction Potential in Mice Treated with Gemfibrozil.Species-related exposure of phase II metabolite gemfibrozil 1-O-β-glucuronide between human and mice: A net induction of mouse P450 activity was revealed.

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Metabolism of fibrates by cytochrome P450s and UDP-glycosyltransferases in rat and human liver microsomes

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http://www.wikidata.org/entity/Q59290294

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im Februar 2012 veröffentlichter wissenschaftlicher Artikel

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wetenschappelijk artikel

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наукова стаття, опублікована в лютому 2012

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Metabolism of fibrates by cyto ...... rat and human liver microsomes

@en

Metabolism of fibrates by cyto ...... rat and human liver microsomes

@nl

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Metabolism of fibrates by cyto ...... rat and human liver microsomes

@en

Metabolism of fibrates by cyto ...... rat and human liver microsomes

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Metabolism of fibrates by cyto ...... rat and human liver microsomes

@en

Metabolism of fibrates by cyto ...... rat and human liver microsomes

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P1476

Metabolism of fibrates by cyto ...... rat and human liver microsomes

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AiMing Liu

http://www.w3.org/2001/XMLSchema#string

Gary Q. Cheng

http://www.w3.org/2001/XMLSchema#string

Hui Xie

http://www.w3.org/2001/XMLSchema#string

RenKe Dai

http://www.w3.org/2001/XMLSchema#string

YanMi Zhou

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Simultaneous determination of gemfibrozil and its metabolites in plasma and urine by a fully automated high performance liquid chromatographic system.

Prediction of drug clearance by glucuronidation from in vitro data: use of combined cytochrome P450 and UDP-glucuronosyltransferase cofactors in alamethicin-activated human liver microsomes.

Comparative toxicity and safety profile of fenofibrate and other fibric acid derivatives.

PPARalpha agonist-induced rodent tumors: modes of action and human relevance.

Microsomal prediction of in vivo clearance of CYP2C9 substrates in humans.

In vitro-in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: pitfalls and promises.

Peroxisome proliferation and hepatocarcinogenesis.

Disposition, metabolism and pharmacokinetics of antihyperlipidemic agents in laboratory animals and man.

Substrate depletion approach for determining in vitro metabolic clearance: time dependencies in hepatocyte and microsomal incubations.

Clinical pharmacokinetics of fibric acid derivatives (fibrates).

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s11434-011-4958-1

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1142-1149

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scholarly article

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10.1007/S11434-011-4958-1

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http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

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2012-02-14T00:00:00Z

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Metabolism of fibrates by cytochrome P450s and UDP-glycosyltransferases in rat and human liver microsomes

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P2860

P2860

Metabolism of fibrates by cytochrome P450s and UDP-glycosyltransferases in rat and human liver microsomes

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P1433

P1476

P2093

P2860

P2888

P304

P31

P356

P433

P478

P577

P356

P1433

P1476

P2093

P2860

P2888

P304

P31

P356

P433

P478

P577