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Kynurenine Aminotransferase Isozyme Inhibitors: A ReviewThe modular structure of haemagglutinin/adhesin regions in gingipains of Porphyromonas gingivalisSelective Inhibition of Human Group IIA-secreted Phospholipase A2 (hGIIA) Signaling Reveals Arachidonic Acid Metabolism Is Associated with Colocalization of hGIIA to Vimentin in Rheumatoid SynoviocytesStructural modelling and dynamics of proteins for insights into drug interactions.Relating structure to function in the beta-propeller domain of dipeptidyl peptidase IV. Point mutations that influence adenosine deaminase binding, antibody binding and enzyme activity.Modelling the structures of G protein-coupled receptors aided by three-dimensional validation.Molecular pathogenesis of liver disease: an approach to hepatic inflammation, cirrhosis and liver transplant tolerance.Phage display as a technology delivering on the promise of peptide drug discovery.In silico evaluation of the influence of the translocon on partitioning of membrane segments.Functional analysis of novel polymorphisms in the human SLCO1A2 gene that encodes the transporter OATP1A2Rhodopsin: structure, signal transduction and oligomerisation.The dipeptidyl peptidase IV family in cancer and cell biology.Essential structural features of novel antischizophrenic drugs: a review.Kynurenine Aminotransferases and the Prospects of Inhibitors for the Treatment of Schizophrenia.Neutron scattering shows a droplet of oleic acid at the center of the BAMLET complex.Expression, purification and crystallization of human kynurenine aminotransferase 2 exploiting a highly optimized codon set.Marked differences in the structures and protein associations of lymphocyte and monocyte CD4: resolution of a novel CD4 isoform.Allosteric modulation of the calcium-sensing receptor by gamma-glutamyl peptides: inhibition of PTH secretion, suppression of intracellular cAMP levels, and a common mechanism of action with L-amino acids.A missense mutation in kynurenine aminotransferase-1 in spontaneously hypertensive rats.Small-angle X-ray scattering of BAMLET at pH 12: a complex of α-lactalbumin and oleic acid.Inhibition of human kynurenine aminotransferase isozymes by estrogen and its derivatives.High resolution crystal structures of human kynurenine aminotransferase-I bound to PLP cofactor, and in complex with aminooxyacetate.Study of the Activity and Possible Mechanism of Action of a Reversible Inhibitor of Recombinant Human KAT-2: A Promising Lead in Neurodegenerative and Cognitive Disorders.Kink characterization and modeling in transmembrane protein structures.Homology modeling of human kynurenine aminotransferase III and observations on inhibitor binding using molecular docking.Improvement of kynurenine aminotransferase-II inhibitors guided by mimicking sulfate esters.Structural and functional consequences of succinate dehydrogenase subunit B mutations.BAMLET kills chemotherapy-resistant mesothelioma cells, holding oleic acid in an activated cytotoxic stateThe molecular structure of the IsiA–Photosystem I supercomplex, modelled from high-resolution, crystal structures of Photosystem I and the CP43 proteinBinding to human dipeptidyl peptidase IV by adenosine deaminase and antibodies that inhibit ligand binding involves overlapping, discontinuous sites on a predicted β propeller domainStructure and Potential Cellular Targets of HAMLET-like Anti-Cancer Compounds made from Milk ComponentsCrystallization and preliminary X-ray diffraction studies of a new crystal form of human secretory type IIA phospholipase A2The function of conserved amino acid residues adjacent to the effector domain in elongation factor GA novel approach to the design of inhibitors of human secreted phospholipase A2 based on native peptide inhibitionMolecular modelling and site-directed mutagenesis of human GALR1 galanin receptor defines determinants of receptor subtype specificityPrediction of rotational orientation of transmembrane helical segments of integral membrane proteins using new environment-based propensities for amino acids derived from structural analysesComparative modeling of marsupial MHC class I molecules identifies structural polymorphisms affecting functional motifsDesign and synthesis of novel inhibitors of human kynurenine aminotransferase-IThe use of soluble protein structures in modeling helical proteins in a layered membraneFragment Screening of Human Kynurenine Aminotransferase-II
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researcher ORCID ID = 0000-0002-8033-5518
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wetenschapper
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W. Bret Church
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W. Bret Church
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W. Bret Church
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W. Bret Church
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W. Bret Church
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W. Bret Church
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W. Bret Church
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W. Bret Church
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W. Bret Church
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W. Bret Church
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W. Bret Church
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W. Bret Church
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W. Bret Church
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W. Bret Church
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W. Bret Church
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0000-0002-8033-5518