about
Exploring the chemical space around 8-mercaptoguanine as a route to new inhibitors of the folate biosynthesis enzyme HPPKKv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseasesStructure-based design and development of functionalized Mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureusDicarba analogues of α-conotoxin RgIA. Structure, stability, and activity at potential pain targetsA Naturally Occurring Peptide with an Elementary Single Disulfide-Directed β-Hairpin FoldVPS29 is not an active metallo-phosphatase but is a rigid scaffold required for retromer interaction with accessory proteinsDistribution and kinetics of the Kv1.3-blocking peptide HsTX1[R14A] in experimental rats.Interactions of disulfide-deficient selenocysteine analogs of μ-conotoxin BuIIIB with the α-subunit of the voltage-gated sodium channel subtype 1.3.A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseasesA novel inhibitor of α9α10 nicotinic acetylcholine receptors from Conus vexillum delineates a new conotoxin superfamily.Conformational flexibility in the binding surface of the potassium channel blocker ShK.N-Terminally extended analogues of the K⁺ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3.Structural Basis for the Inhibition of Voltage-gated Sodium Channels by Conotoxin μO§-GVIIJ.A potent and selective peptide blocker of the Kv1.3 channel: prediction from free-energy simulations and experimental confirmationCrystallization and preliminary X-ray analysis of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus.Exploration of rate-limiting conformational state for 5-[(7-chloro-4-quinolinyl)amino]-3-[(alkylamino)methyl][1,1'-biphenyl]-2-ols and N(omega)-oxides (tebuquine analogues) for antimalarial activity using molecular shape analysis and molecular fieldCDK4/6 Inhibition Augments Anti-Tumor Immunity by Enhancing T Cell Activation.Installation of a Rigid EDTA-Like Motif into a Protein α-Helix for Paramagnetic NMR Spectroscopy with Cobalt(II) Ions.8-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase.15N detection harnesses the slow relaxation property of nitrogen: Delivering enhanced resolution for intrinsically disordered proteins.Reinvestigation of the biological activity of d-allo-ShK protein.Structure and activity of contryphan-Vc2: Importance of the d-amino acid residue.DOTA-Amide Lanthanide Tag for Reliable Generation of Pseudocontact Shifts in Protein NMR SpectraEngineering of a bis-chelator motif into a protein α-helix for rigid lanthanide binding and paramagnetic NMR spectroscopyAn iminodiacetic acid based lanthanide binding tag for paramagnetic exchange NMR spectroscopyStereoselective synthesis and structural elucidation of dicarba peptidesA potent cyclic peptide targeting SPSB2 protein as a potential anti-infective agentAromatic 19F-13C TROSY: a background-free approach to probe biomolecular structure, function, and dynamics
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P50
description
researcher ORCID ID = 0000-0002-5225-1333
@en
name
Sandeep Chhabra
@ast
Sandeep Chhabra
@en
Sandeep Chhabra
@es
Sandeep Chhabra
@nl
type
label
Sandeep Chhabra
@ast
Sandeep Chhabra
@en
Sandeep Chhabra
@es
Sandeep Chhabra
@nl
prefLabel
Sandeep Chhabra
@ast
Sandeep Chhabra
@en
Sandeep Chhabra
@es
Sandeep Chhabra
@nl
P21
P31
P496
0000-0002-5225-1333