about
Citrullination of collagen II affects integrin-mediated cell adhesion in a receptor-specific mannerCollagen XXIII, novel ligand for integrin alpha2beta1 in the epidermisJararhagin-derived RKKH peptides induce structural changes in alpha1I domain of human integrin alpha1beta1The R78K and D117E active-site variants of Saccharomyces cerevisiae soluble inorganic pyrophosphatase: structural studies and mechanistic implicationsDistinct recognition of collagen subtypes by alpha(1)beta(1) and alpha(2)beta(1) integrins. Alpha(1)beta(1) mediates cell adhesion to type XIII collagenMolecular mechanism of alpha2beta1 integrin interaction with human echovirus 1.Molecular mechanism of T-cell protein tyrosine phosphatase (TCPTP) activation by mitoxantrone.Early chordate origin of the vertebrate integrin αI domains.Sulfonamide inhibitors of α2β1 integrin reveal the essential role of collagen receptors in in vivo models of inflammation.Evolution of collagen-based adhesion systems.A peptide inhibiting the collagen binding function of integrin alpha2I domain.Joint inflammation related citrullination of functional arginines in extracellular proteins.Novel α2β1 integrin inhibitors reveal that integrin binding to collagen under shear stress conditions does not require receptor preactivation.Structural and functional analysis of integrin alpha2I domain interaction with echovirus 1.Integrin-mediated cell adhesion to type I collagen fibrils.A small-molecule inhibitor of integrin alpha2 beta1 introduces a new strategy for antithrombotic therapy.Extracellular citrullination inhibits the function of matrix associated TGF-β.The binding capacity of α1β1-, α2β1- and α10β1-integrins depends on non-collagenous surface macromolecules rather than the collagens in cartilage fibrils.Small molecule designed to target metal binding site in the alpha2I domain inhibits integrin function.Proline hydroxylation in collagen supports integrin binding by two distinct mechanisms.Effect of D97E substitution on the kinetic and thermodynamic properties of Escherichia coli inorganic pyrophosphatase.Structure and function analysis of Escherichia coli inorganic pyrophosphatase: is a hydroxide ion the key to catalysis?Integrin α2I Domain Recognizes Type I and Type IV Collagens by Different Mechanisms“RKKH” Peptides from the Snake Venom Metalloproteinase ofBothrops jararacaBind Near the Metal Ion-dependent Adhesion Site of the Human Integrin α2I-domainEffect of E20D Substitution in the Active Site ofEscherichia coliInorganic Pyrophosphatase on Its Quaternary Structure and Catalytic Properties†Analysis of recombinant human alpha 1 integrin I-domain with a function-blocking monoclonal antibody, 1B3.1.Analysis of cell-free human alpha1 integrin with a monoclonal antibody to the I-domain: detection in ocular fluid and function as an adhesion substrateProduction, crystallization and preliminary X-ray analysis of the human integrin alpha1 I domainAnalysis of an ascidian integrin provides new insight into early evolution of collagen recognitionFluorescent small molecule probe to modulate and explore α2β1 integrin functionIn vitro blood and fibroblast responses to BisGMA-TEGDMA/bioactive glass composite implants
P50
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P50
description
researcher ORCID ID = 0000-0003-3036-713X
@en
name
Jarmo Käpylä
@ast
Jarmo Käpylä
@en
Jarmo Käpylä
@nl
type
label
Jarmo Käpylä
@ast
Jarmo Käpylä
@en
Jarmo Käpylä
@nl
prefLabel
Jarmo Käpylä
@ast
Jarmo Käpylä
@en
Jarmo Käpylä
@nl
P31
P496
0000-0003-3036-713X