about
Combating ovarian aging depends on the use of existing ovarian follicles, not on putative oogonial stem cellsPharmacological inhibition of mTORC1 prevents over-activation of the primordial follicle pool in response to elevated PI3K signalingMastl is required for timely activation of APC/C in meiosis I and Cdk1 reactivation in meiosis IIExperimental evidence showing that no mitotically active female germline progenitors exist in postnatal mouse ovariesTsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial folliclesmTORC1 Signaling in oocytes is dispensable for the survival of primordial follicles and for female fertility.Inhibitory phosphorylation of Cdk1 mediates prolonged prophase I arrest in female germ cells and is essential for female reproductive lifespan.Molecular mechanisms underlying the activation of mammalian primordial follicles.Genetically modified mouse models for premature ovarian failure (POF).MASTL is essential for anaphase entry of proliferating primordial germ cells and establishment of female germ cells in mice.The regulation of maturation promoting factor during prophase I arrest and meiotic entry in mammalian oocytes.Cdk2 catalytic activity is essential for meiotic cell division in vivo.mTOR signaling in the control of activation of primordial follicles.Cdk1 drives meiosis and mitosis through two different mechanisms.Disruption of Tsc2 in oocytes leads to overactivation of the entire pool of primordial follicles.Cyclin A2 modulates kinetochore-microtubule attachment in meiosis II.Oocyte-specific deletion of Pten causes premature activation of the primordial follicle pool.Animal Models for Studying the In Vivo Functions of Cell Cycle CDKs.
P50
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P50
description
researcher ORCID ID = 0000-0002-3404-8753
@en
name
Deepak Adhikari
@ast
Deepak Adhikari
@en
Deepak Adhikari
@es
Deepak Adhikari
@nl
type
label
Deepak Adhikari
@ast
Deepak Adhikari
@en
Deepak Adhikari
@es
Deepak Adhikari
@nl
prefLabel
Deepak Adhikari
@ast
Deepak Adhikari
@en
Deepak Adhikari
@es
Deepak Adhikari
@nl
P106
P1153
23484470100
P31
P496
0000-0002-3404-8753