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The amino-terminus of nitric oxide sensitive guanylyl cyclase α₁ does not affect dimerization but influences subcellular localizationFluorescent fusion proteins of soluble guanylyl cyclase indicate proximity of the heme nitric oxide domain and catalytic domain.Heme oxygenase isoforms differ in their subcellular trafficking during hypoxia and are differentially modulated by cytochrome P450 reductase.Direct fusion of subunits of heterodimeric nitric oxide sensitive guanylyl cyclase leads to functional enzymes with preserved biochemical properties: evidence for isoform specific activation by ciguates.PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia.Nanoparticle targeting to the endothelium during normothermic machine perfusion of human kidneys.
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description
onderzoeker
@nl
researcher ORCID ID = 0000-0002-0979-2900
@en
name
Jan R Kraehling
@ast
Jan R Kraehling
@en
Jan R Kraehling
@es
Jan R Kraehling
@nl
type
label
Jan R Kraehling
@ast
Jan R Kraehling
@en
Jan R Kraehling
@es
Jan R Kraehling
@nl
prefLabel
Jan R Kraehling
@ast
Jan R Kraehling
@en
Jan R Kraehling
@es
Jan R Kraehling
@nl
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P1153
36241674600
P31
P496
0000-0002-0979-2900