about
Meiotic studies of a human male carrier of the common translocation, t(11;22), suggests postzygotic selection rather than preferential 3:1 MI segregation as the cause of liveborn offspring with an unbalanced translocation.Excess single-stranded DNA inhibits meiotic double-strand break repair.Human RECQL5 overcomes thymidine-induced replication stress.Modeling meiotic chromosomes indicates a size dependent contribution of telomere clustering and chromosome rigidity to homologue juxtaposition.Compartmentalization of the yeast meiotic nucleus revealed by analysis of ectopic recombinationRestriction of ectopic recombination by interhomolog interactions during Saccharomyces cerevisiae meiosis.Essential and Checkpoint Functions of Budding Yeast ATM and ATR during Meiotic Prophase Are Facilitated by Differential Phosphorylation of a Meiotic Adaptor Protein, Hop1Local chromosome context is a major determinant of crossover pathway biochemistry during budding yeast meiosis.Meiotic recombination hotspots.Evidence that MEK1 positively promotes interhomologue double-strand break repairCorrection: Essential and Checkpoint Functions of Budding Yeast ATM and ATR during Meiotic Prophase Are Facilitated by Differential Phosphorylation of a Meiotic Adaptor Protein, Hop1.Separable roles for Exonuclease I in meiotic DNA double-strand break repair.Mre11 and Exo1 contribute to the initiation and processivity of resection at meiotic double-strand breaks made independently of Spo11.Subtelomeric breakage and chromosome exchangeMeiotic analysis by FISH of a human male 46,XY,t(15;20)(q11.2;q11.2) translocation heterozygote: quadrivalent configuration, orientation and first meiotic segregationAnalysis of chiasma frequency and first meiotic segregation in a human male reciprocal translocation heterozygote, t(1;11)(p36.3;q13.1), using fluorescence in situ hybridisationThe relationship between meiotic chromosome pairing and chiasma formationWild-type levels of Spo11-induced DSBs are required for normal single-strand resection during meiosisS. cerevisiae Srs2 helicase ensures normal recombination intermediate metabolism during meiosis and prevents accumulation of Rad51 aggregatesMethyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable DNA double-strand breaks
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description
researcher ORCID ID = 0000-0002-0516-3197
@en
wetenschapper
@nl
name
Alastair S Goldman
@ast
Alastair S Goldman
@en
Alastair S Goldman
@es
Alastair S Goldman
@nl
type
label
Alastair S Goldman
@ast
Alastair S Goldman
@en
Alastair S Goldman
@es
Alastair S Goldman
@nl
prefLabel
Alastair S Goldman
@ast
Alastair S Goldman
@en
Alastair S Goldman
@es
Alastair S Goldman
@nl
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P106
P1153
57189228573
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0000-0002-0516-3197