about
Tetrahydrofolic Acid is a potent suicide substrate of mushroom tyrosinaseSuicide inactivation of tyrosinase in its action on tetrahydropterinesOxidation by mushroom tyrosinase of monophenols generating slightly unstable o-quinones.Promoting E2F1-mediated apoptosis in oestrogen receptor-α-negative breast cancer cellsMechanisms of compound I formation in heme peroxidases.Directed phenotype switching as an effective antimelanoma strategy.Reactivation of the tumour suppressor RASSF1A in breast cancer by simultaneous targeting of DNA and E2F1 methylation.A review on spectrophotometric methods for measuring the monophenolase and diphenolase activities of tyrosinase.Suicide inactivation of the diphenolase and monophenolase activities of tyrosinase.Targeting the epigenetic machinery of cancer cells.Factors influencing the antifolate activity of synthetic tea-derived catechins.Melanoma coordinates general and cell-specific mechanisms to promote methotrexate resistance.Comparison of a pair of synthetic tea-catechin-derived epimers: synthesis, antifolate activity, and tyrosinase-mediated activation in melanoma.Mechanism of dihydrofolate reductase downregulation in melanoma by 3-O-(3,4,5-trimethoxybenzoyl)-(-)-epicatechin.The critical role of alpha-folate receptor in the resistance of melanoma to methotrexate.The anti-inflammatory and anti-cancer properties of epigallocatechin-3-gallate are mediated by folate cycle disruption, adenosine release and NF-kappaB suppression.Targeting the methionine cycle for melanoma therapy with 3-O-(3,4,5-trimethoxybenzoyl)-(-)-epicatechin.Synthesis and biological activity of a 3,4,5-trimethoxybenzoyl ester analogue of epicatechin-3-gallate.Kinetic study of the inactivation of ascorbate peroxidase by hydrogen peroxide.Deuterium isotope effect on the oxidation of monophenols and o-diphenols by tyrosinase.Purification and kinetic properties of human recombinant dihydrofolate reductase produced in Bombyx mori chrysalides.Effects of tetrahydropterines on the generation of quinones catalyzed by tyrosinase.Binding of natural and synthetic polyphenols to human dihydrofolate reductase.Analysis of cholinesterases in human prostate and sperm: implications in cancer and fertility.Melanogenesis inhibition by tetrahydropterines.Hydroxylation of p-substituted phenols by tyrosinase: further insight into the mechanism of tyrosinase activity.Analysis and interpretation of the action mechanism of mushroom tyrosinase on monophenols and diphenols generating highly unstable o-quinones.The inactivation of horseradish peroxidase isoenzyme A2 by hydrogen peroxide: an example of partial resistance due to the formation of a stable enzyme intermediate.Indirect inactivation of tyrosinase in its action on 4-tert-butylphenol.Kinetic characterisation of the reaction mechanism of mushroom tyrosinase on tyramine/dopamine and L-tyrosine methyl esther/L-dopa methyl esther.Method for the determination of molar absorptivities of thiol adducts formed from diphenolic substrates of polyphenol oxidase.Compound I formation in artichoke (Cynara scolymus L.) peroxidase is modulated by the equilibrium between pentacoordinated and 6-aquo hexacoordinated forms of the heme and by calcium ions.Kinetic study of the effects of calcium ions on cationic artichoke (Cynara scolymus L.) peroxidase: calcium binding, steady-state kinetics and reactions with hydrogen peroxide.Kinetic characterization of the oxidation of carbidopa and benserazide by tyrosinase and peroxidase.Generation of hydrogen peroxide in the melanin biosynthesis pathway.Melanoma activation of 3-o-(3,4,5-trimethoxybenzoyl)-(-)-epicatechin to a potent irreversible inhibitor of dihydrofolate reductase.Determination and applications of the molar absorptivity of phenolic adducts with captopril and mesna.Stereospecific inactivation of tyrosinase by L- and D-ascorbic acid.Ellagic acid: characterization as substrate of polyphenol oxidase.Kinetic characterization of the enzymatic and chemical oxidation of the catechins in green tea.
P50
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P50
description
researcher ORCID ID = 0000-0001-6863-1173
@en
wetenschapper
@nl
name
José Neptuno Rodríguez-López
@ast
José Neptuno Rodríguez-López
@en
José Neptuno Rodríguez-López
@es
José Neptuno Rodríguez-López
@nl
type
label
José Neptuno Rodríguez-López
@ast
José Neptuno Rodríguez-López
@en
José Neptuno Rodríguez-López
@es
José Neptuno Rodríguez-López
@nl
prefLabel
José Neptuno Rodríguez-López
@ast
José Neptuno Rodríguez-López
@en
José Neptuno Rodríguez-López
@es
José Neptuno Rodríguez-López
@nl
P106
P1153
35584818100
P21
P31
P496
0000-0001-6863-1173