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Evolution of melanopsin photoreceptors: discovery and characterization of a new melanopsin in nonmammalian vertebratesAddition of human melanopsin renders mammalian cells photoresponsiveHuman melanopsin forms a pigment maximally sensitive to blue light (λmax ≈ 479 nm) supporting activation of G(q/11) and G(i/o) signalling cascadesMelanopsin cells are the principal conduits for rod-cone input to non-image-forming visionMelanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in miceColour as a signal for entraining the mammalian circadian clockNeuropsin (Opn5): a novel opsin identified in mammalian neural tissueTemporal and spatial expression patterns of the CRX transcription factor and its downstream targets. Critical differences during human and mouse eye developmentDifferential expression of two distinct functional isoforms of melanopsin (Opn4) in the mammalian retinaMelanopsin-dependent photoreception provides earliest light detection in the mammalian retina.Melanopsin-driven increases in maintained activity enhance thalamic visual response reliability across a simulated dawnVisual responses in mice lacking critical components of all known retinal phototransduction cascades.Melanopsin Contributions to the Representation of Images in the Early Visual System.Regulation of mammalian circadian behavior by non-rod, non-cone, ocular photoreceptors.Regulation of the mammalian pineal by non-rod, non-cone, ocular photoreceptors.Distinct contributions of rod, cone, and melanopsin photoreceptors to encoding irradiance.Reproducible and sustained regulation of Gαs signalling using a metazoan opsin as an optogenetic toolDiminished pupillary light reflex at high irradiances in melanopsin-knockout mice.Adaptation of pineal expressed teleost exo-rod opsin to non-image forming photoreception through enhanced Meta II decay.Expression of opsin genes early in ocular development of humans and mice.A "melanopic" spectral efficiency function predicts the sensitivity of melanopsin photoreceptors to polychromatic lights.Identifying the photoreceptive inputs to the mammalian circadian system using transgenic and retinally degenerate mice.Cartilage repair using human embryonic stem cell-derived chondroprogenitors.The melanopic sensitivity function accounts for melanopsin-driven responses in mice under diverse lighting conditionsGlycosidic enzymes enhance retinal transduction following intravitreal delivery of AAV2.Retinal output changes qualitatively with every change in ambient illuminanceNon-rod, non-cone photoreception in rodents and teleost fish.Encephalic photoreception and phototactic response in the troglobiont Somalian blind cavefish Phreatichthys andruzzii.Optogenetic interrogation reveals separable G-protein-dependent and -independent signalling linking G-protein-coupled receptors to the circadian oscillator.Spatial receptive fields in the retina and dorsal lateral geniculate nucleus of mice lacking rods and cones.Neural reprogramming in retinal degeneration.Visual responses in the lateral geniculate evoked by Cx36-independent rod pathways.The electroretinogram as a method for studying circadian rhythms in the mammalian retina.Chemogenetic Activation of ipRGCs Drives Changes in Dark-Adapted (Scotopic) Electroretinogram.Convergence of visual and whisker responses in the primary somatosensory thalamus (ventral posterior medial region) of the mouseHow rod, cone, and melanopsin photoreceptors come together to enlighten the mammalian circadian clock.Responses to Spatial Contrast in the Mouse Suprachiasmatic NucleiChromatic clocks: Color opponency in non-image-forming visual function.Chemogenetic Activation of Melanopsin Retinal Ganglion Cells Induces Signatures of Arousal and/or Anxiety in Mice.2-Aminoethoxydiphenylborane is an acute inhibitor of directly photosensitive retinal ganglion cell activity in vitro and in vivo.
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description
researcher ORCID ID = 0000-0002-1088-8029
@en
wetenschapper
@nl
name
Robert J Lucas
@ast
Robert J Lucas
@en
Robert J Lucas
@es
Robert J Lucas
@nl
type
label
Robert J Lucas
@ast
Robert J Lucas
@en
Robert J Lucas
@es
Robert J Lucas
@nl
prefLabel
Robert J Lucas
@ast
Robert J Lucas
@en
Robert J Lucas
@es
Robert J Lucas
@nl
P1153
P106
P1153
55825862900
57193815136
57203258611
7201704107
P31
P496
0000-0002-1088-8029