about
Concerted activity of IgG1 antibodies and IL-4/IL-25-dependent effector cells trap helminth larvae in the tissues following vaccination with defined secreted antigens, providing sterile immunity to challenge infectionInnate and adaptive type 2 immune cell responses in genetically controlled resistance to intestinal helminth infectionC-type lectins from the nematode parasites Heligmosomoides polygyrus and Nippostrongylus brasiliensis.Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway.Secretion of protective antigens by tissue-stage nematode larvae revealed by proteomic analysis and vaccination-induced sterile immunity.CCR7-dependent trafficking of RORγ⁺ ILCs creates a unique microenvironment within mucosal draining lymph nodes.Low-level regulatory T-cell activity is essential for functional type-2 effector immunity to expel gastrointestinal helminths.Proteomic analysis of secretory products from the model gastrointestinal nematode Heligmosomoides polygyrus reveals dominance of venom allergen-like (VAL) proteinsCommensal-pathogen interactions in the intestinal tract: lactobacilli promote infection with, and are promoted by, helminth parasites.Immune modulation and modulators in Heligmosomoides polygyrus infection.ILC2s and T cells cooperate to ensure maintenance of M2 macrophages for lung immunity against hookworms.The role of ILC2 in hookworm infection.Suppression of type 2 immunity and allergic airway inflammation by secreted products of the helminth Heligmosomoides polygyrus.HpARI Protein Secreted by a Helminth Parasite Suppresses Interleukin-33Corrigendum: CCR7-dependent trafficking of RORγ(+) ILCs creates a unique microenvironment within mucosal draining lymph nodes.A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells.The Study of Host Immune Responses Elicited by the Model Murine Hookworms Nippostrongylus brasiliensis and Heligmosomoides polygyrus.A novel blood-feeding detoxification pathway in Nippostrongylus brasiliensis L3 reveals a potential checkpoint for arresting hookworm development.Immunity without innate lymphoid cells.Intestinal helminth infection promotes IL-5- and CD4 T cell-dependent immunity in the lung against migrating parasitesMacrophage Migration Inhibitory Factor (MIF) Is Essential for Type 2 Effector Cell Immunity to an Intestinal Helminth Parasite
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description
researcher ORCID ID = 0000-0001-5758-5730
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wetenschapper
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name
Kara J Filbey
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Kara J Filbey
@en
Kara J Filbey
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type
label
Kara J Filbey
@ast
Kara J Filbey
@en
Kara J Filbey
@nl
prefLabel
Kara J Filbey
@ast
Kara J Filbey
@en
Kara J Filbey
@nl
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0000-0001-5758-5730